A self-healable, moldable and bioactive biomaterial gum for personalised and wearable drug delivery

被引:14
作者
Shahbazi, Mohammad-Ali [1 ,2 ]
Shrestha, Neha [3 ]
Pierchala, Malgorzata Karolina [4 ]
Kadumudi, Firoz Babu [4 ]
Mehrali, Mehdi [4 ,5 ]
Hasany, Masoud [4 ]
Preat, Veronique [3 ]
Leeuwenburgh, Sander [6 ]
Dolatshahi-Pirouz, Alireza [4 ,6 ]
机构
[1] Tech Univ Denmark, Dept Micro & Nanotechnol, Orsteds Plads, DK-2800 Lyngby, Denmark
[2] Zanjan Univ Med Sci, Sch Pharm, Dept Pharmaceut Nanotechnol, Zanjan, Iran
[3] Catholic Univ Louvain, Louvain Drug Res Inst, Adv Drug Delivery & Biomat, B-1200 Brussels, Belgium
[4] Tech Univ Denmark, Ctr Intestinal Absorpt & Transport Biopharmaceut, Dept Hlth Technol, DK-2800 Lyngby, Denmark
[5] Tech Univ Denmark, Dept Mech Engn, DK-2800 Lyngby, Denmark
[6] Radboud Univ Nijmegen, Dept Dent Regenerat Biomat, Med Ctr, Philips van Leydenlaan 25, NL-6525 EX Nijmegen, Netherlands
基金
欧盟地平线“2020”;
关键词
TANNIC-ACID; MECHANICAL-PROPERTIES; POLY(VINYL ALCOHOL); SHAPE-MEMORY; IN-VITRO; HYDROGELS; TOUGHNESS; STRENGTH; ANTIBACTERIAL; DERIVATIVES;
D O I
10.1039/c9tb02156f
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
One of the long-standing challenges in materials science involves synthesizing biomaterials that recapitulate important features of native biological tissues. Even though, the number of available biomaterials at the moment are virtually limitless, few of them has unlocked all the secrets of the human body by mimicking the combinatorial-like material properties of our tissues and organs. Inspired by the human body, we have developed a polymeric gum, which combines stretchability, toughness, strength, flexibility, and self-healing. It also exhibits a high bioactivity that can target and eliminate bacterial infections fast and reliably. Notably, this material is moldable into almost any complex shape, and therefore suitable as a building block for wearables designed to conform directly with the curved and personalized anatomy of patients. It also exhibits excellent drug retention and release capacity, which altogether makes it suitable for applications in personalized wearable drug-delivery devices.
引用
收藏
页码:4340 / 4356
页数:17
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