Fast Multidimensional NMR Spectroscopy Using Compressed Sensing

被引：174

作者：

Holland, Daniel J. ^{[2
]}

Bostock, Mark J. ^{[1
]}

Gladden, Lynn F. ^{[2
]}

Nietlispach, Daniel ^{[1
]}

机构：

[1] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England

[2] Univ Cambridge, Dept Chem Engn & Biotechnol, Cambridge CB2 3RA, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 29期

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

compressed sensing; multidimensional NMR spectroscopy; nonuniform sampling; proteins; structure elucidation; FOURIER-TRANSFORM; SPECTRA; ACQUISITION; RECONSTRUCTION; RECEPTOR;

D O I：

10.1002/anie.201100440

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Make it snappy! The use of compressed sensing to reconstruct multidimensional NMR spectra enables significant reductions in recording time. Thus, 3D HNCA (blue) and HN(CO)CA spectra (green) of sufficient quality for rapid protein-backbone assignment were reconstructed from only 16% of the fully sampled data. The generality of the method and its robustness to noise should make it more broadly applicable, for example, to solid-state NMR spectroscopy. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6548 / 6551

页数：4

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