Peptides corresponding to the heptad repeat motifs in the transmembrane protein (gp41) of human immunodeficiency virus type 1 elicit antibodies to receptor-activated conformations of the envelope glycoprotein

被引：52

作者：

De Rosny, E

Vassell, R

Wingfield, PT

Wild, CT

Weiss, CD

机构：

[1] US FDA, Ctr Biol Evaluat & Res, Off Vaccines, Bethesda, MD 20892 USA

[2] NIAMSD, Prot Express Lab, NIH, Bethesda, MD 20892 USA

[3] Panacos Pharmaceut, Gaithersburg, MD USA

来源：

JOURNAL OF VIROLOGY | 2001年 / 75卷 / 18期

关键词：

D O I：

10.1128/JVI.75.18.8859-8863.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Two heptad repeat regions in the ectodomain of the human immunodeficiency virus type 1 (HIV-1) transmembrane subunit (gp41) self-assemble into a six-helix bundle structure that is critical for virus entry. Immunizations with peptides corresponding to these regions generated antibodies specific to the receptor-activated conformations of gp41.

引用

收藏

页码：8859 / 8863

页数：5

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