Optical detection of deoxyribonucleic acid hybridization using an anchoring transition of liquid crystal alignment

被引：33

作者：

Kim, HR ^{[1
]}

Kim, JH

Kim, TS

Oh, SW

Choi, EY

机构：

[1] Hanyang Univ, Dept Elect & Comp Engn, Seoul 133791, South Korea

[2] Hallym Univ, Dept Chem, Chunchon 200702, Kangwon Do, South Korea

[3] Boditech Inc, Cent Res Inst, Chunchon 200702, Kangwon Do, South Korea

[4] Hallym Univ, Dept Genet Engn, Chunchon 200702, Kangwon Do, South Korea

来源：

APPLIED PHYSICS LETTERS | 2005年 / 87卷 / 14期

关键词：

D O I：

10.1063/1.2077859

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

We demonstrate an optical method for detecting specific binding events in an oligo deoxyribonucleic acid (DNA) chip using an anchoring transition of a nematic liquid crystal (NLC) as a result of DNA hybridization. A homeotropic orientation of the NLC supported by oligoDNA changes to a random planar orientation after hybridization. Such DNA hybridization and subsequent NLC reorientation are easily observable with a simple detection system via long-range orientational order and large optical anisotropy of the NLC. (C) 2005 American Institute of Physics.

引用

页码：1 / 3

页数：3

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