Deciphering the Enigma of the Histone H2A.Z-1/H2A.Z-2 Isoforms: Novel Insights and Remaining Questions

被引：7

作者：

Cheema, Manjinder S. ^{[1
]}

Good, Katrina V. ^{[1
]}

Kim, Bohyun ^{[1
]}

Soufari, Heddy ^{[2
,3
]}

O'Sullivan, Connor ^{[1
]}

Freeman, Melissa E. ^{[1
]}

Stefanelli, Gilda ^{[4
]}

Casas, Ciro Rivera ^{[5
]}

Zengeler, Kristine E. ^{[6
]}

Kennedy, Andrew J. ^{[6
]}

Lopez, Jose Maria Eirin ^{[5
]}

Howard, Perry L. ^{[1
]}

Zovkic, Iva B. ^{[4
,7
]}

Shabanowitz, Jeffrey ^{[8
]}

Dryhurst, Deanna D. ^{[1
]}

Hunt, Donald F. ^{[8
,9
]}

Mackereth, Cameron D. ^{[2
,3
]}

Ausio, Juan ^{[1
]}

机构：

[1] Univ Victoria, Dept Biochem & Microbiol, Victoria, BC V8W 3P6, Canada

[2] Univ Bordeaux, Inst Europeen Chim & Biol, 2 Rue Robert Escarpit, F-33607 Pessac, France

[3] Univ Bordeaux, CNRS, UMR 5320, INSERM,U1212,ARNA Lab, 146 Rue Leo Saignat, F-33076 Bordeaux, France

[4] Hosp Sick Children, Dept Neurosci & Mental Hlth, Toronto, ON M5G 1X8, Canada

[5] Florida Int Univ North, Dept Biol Sci, Environm Epigenet Grp, Miami, FL 33181 USA

[6] Bates Coll, Dept Chem & Biochem, 2 Andrews Rd, Lewiston, ME 04240 USA

[7] Univ Toronto Mississauga, Dept Psychol, Mississauga, ON L5L 1C6, Canada

[8] Univ Virginia, Dept Chem, Charlottesville, VA 22904 USA

[9] Univ Virginia, Dept Pathol, Charlottesville, VA 22903 USA

来源：

CELLS | 2020年 / 9卷 / 05期

基金：

美国国家科学基金会; 加拿大健康研究院;

关键词：

replication dependent (RD) and replication independent (RI) histone variants; H2A; Z-1 and H2A; Z-2; evolution; NMR; transcription; spermatogenesis; development; NUCLEOSOME CORE PARTICLE; N-TERMINAL TAIL; VARIANT H2A.Z; DNA-METHYLATION; SWR1; COMPLEX; MESENCHYMAL TRANSITION; CRYSTAL-STRUCTURE; VERTEBRATE H2A.Z; CELL-CYCLE; CHROMATIN;

D O I：

10.3390/cells9051167

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The replication independent (RI) histone H2A.Z is one of the more extensively studied variant members of the core histone H2A family, which consists of many replication dependent (RD) members. The protein has been shown to be indispensable for survival, and involved in multiple roles from DNA damage to chromosome segregation, replication, and transcription. However, its functional involvement in gene expression is controversial. Moreover, the variant in several groups of metazoan organisms consists of two main isoforms (H2A.Z-1 and H2A.Z-2) that differ in a few (3-6) amino acids. They comprise the main topic of this review, starting from the events that led to their identification, what is currently known about them, followed by further experimental, structural, and functional insight into their roles. Despite their structural differences, a direct correlation to their functional variability remains enigmatic. As all of this is being elucidated, it appears that a strong functional involvement of isoform variability may be connected to development.

引用

页数：21

共 103 条

[1] THE HISTONE FOLD - A UBIQUITOUS ARCHITECTURAL MOTIF UTILIZED IN DNA COMPACTION AND PROTEIN DIMERIZATION [J].