Importance of Allergy in Asthma: An Epidemiologic Perspective

被引:25
作者
Douwes, Jeroen [1 ]
Brooks, Collin [1 ]
van Dalen, Christine [1 ]
Pearce, Neil [1 ]
机构
[1] Massey Univ, Ctr Publ Hlth Res, Wellington 6140, New Zealand
关键词
Asthma; Allergy; Atopy; Time trends; Global patterns; Nonallergic asthma; Epidemiology; Risk factors; Protective factors; Hygiene hypothesis; RESPIRATORY SYMPTOMS; CHILDHOOD ASTHMA; HAY-FEVER; HOUSE-DUST; INCREASING PREVALENCE; TIME TRENDS; MELBOURNE SCHOOLCHILDREN; ATOPIC DISORDERS; NONATOPIC ASTHMA; RISK-FACTORS;
D O I
10.1007/s11882-011-0215-6
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
There has been a global epidemic of asthma during the past half-century. More recently, the prevalence has leveled off or declined in many Western countries, whereas the prevalence in less affluent nations is still increasing. The reasons for this and the different geographical patterns of asthma prevalence remain unclear. This paper provides an epidemiologic perspective on whether allergen exposure and allergies can explain these trends. In particular, the paper discusses 1) geographical and temporal trends in asthma and the role of allergens and allergy, 2) the importance of nonallergic mechanisms, 3) nonallergenic exposures that may modify the risk of allergies and asthma, and 4) new and emerging risk and protective factors. Although allergy and asthma are closely related, allergen exposure and allergy alone cannot explain current time trends and geographical patterns of asthma. Population-based studies focusing on recently identified risk and protective factors may provide further insight.
引用
收藏
页码:434 / 444
页数:11
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