Identification of sialic acid linkage isomers in glycans using coupled InfraRed Multiple Photon Dissociation (IRMPD) spectroscopy and mass spectrometry

被引：32
作者：
Depland, Agathe Depraz [1 ]
Renois-Predelus, Gina [1 ]
Schindler, Baptiste [1 ]
Compagnon, Isabelle [1 ,2 ]
机构：
[1] Univ Claude Bernard Lyon 1, Univ Lyon, CNRS, Inst Lumiere Matiere, F-69622 Villeurbanne, France
[2] IUF, 103 Blvd St Michel, F-75005 Paris, France
来源：
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY | 2018年 / 434卷
关键词：
Ion spectroscopy; IRMPD spectroscopy; Glycomics; Sialic acid; Human milk oligosaccharides; N-glycan epitopes; HUMAN-MILK OLIGOSACCHARIDES; ION MOBILITY; N-GLYCANS; DERIVATIZATION; NOMENCLATURE; HEXOSAMINES; SEPARATION; INFANTS;
D O I：
10.1016/j.ijms.2018.09.005
中图分类号：
O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];
学科分类号：
070203 ; 070304 ; 081704 ; 1406 ;
摘要：
The gas phase IR spectra of alpha 2,3 and alpha 2,6 linkage isomers of sialic acid-containing human milk oligosac-charides and N-glycans epitopes are measured in the 3 mu m spectral range using IRMPD spectroscopy in protonated and Na+ charge states. Each linkage isomer has a unique IRMPD fingerprint, providing a convenient diagnostic of the sialic acid position. Finally, a generic trend is observed: 3-linked sialic acid results in a significant broadening of the spectroscopic signature regardless of the glycan core and the charge state which suggests a drastic influence of the sialic acid position on the glycan conformation. (C) 2018 Elsevier B.V. All rights reserved.
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收藏
页码：65 / 69
页数：5
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