A Radiologist's Perspective on Treatment-Related Pseudoprogression: Clues and Hues

被引：5

作者：

Chakrabarty, Nivedita ^{[1
]}

Mahajan, Abhishek ^{[1
]}

Baheti, Akshay D. ^{[1
]}

Choudhari, Amit ^{[1
]}

Patil, Vasundhara ^{[1
]}

Popat, Palak ^{[1
]}

Unde, Himangi ^{[1
]}

机构：

[1] Homi Bhabha Natl Inst HBNI, Tata Mem Ctr, Tata Mem Hosp, Dept Radiodiag, Mumbai, Maharashtra, India

来源：

INDIAN JOURNAL OF MEDICAL AND PAEDIATRIC ONCOLOGY | 2022年 / 43卷 / 01期

关键词：

pseudoprogression; immunotherapy; radiation therapy; targeted therapy; RENAL-CELL CARCINOMA; RESPONSE CRITERIA; ATTENUATION; RECURRENCE; METASTASES; GLIOMAS; SIZE;

D O I：

10.1055/s-0042-1742609

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pseudoprogression refers to the initial apparent increase in tumor burden observed on imaging after cancer therapy, with subsequent delayed response to the same treatment, thus giving a false initial appearance of disease progression. It is essential to differentiate pseudoprogression from true progression to prevent the patients from getting deprived of the benefits of their ongoing cancer therapy owing to their early withdrawal. It also affects their recruitment for clinical trials. Pseudoprogression, albeit uncommon, has been observed after various types of cancer therapy; however, this phenomenon has gained momentum of late due to the emergence of immunotherapy for the treatment of various malignancies. Besides immunotherapy, pseudoprogression has predominantly been of concern in a few patients after radiation therapy for brain tumors and metastasis, after molecular targeted therapy for a variety of tumors, and after chemotherapy in metastatic bone lesions. This article reviews the available data on imaging of pseudoprogression from various types of cancer therapies, highlighting ways to suspect or identify it on imaging.

引用

页码：52 / 59

页数：8

共 29 条

[1] FDG PET/CT for assessing tumour response to immunotherapy: Report on the EANM symposium on immune modulation and recent review of the literature [J].

Aide, Nicolas ;

Hicks, Rodney J. ;

Le Tourneau, Christophe ;

Lheureux, Stephanie ;

Fanti, Stefano ;

Lopci, Egesta .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2019, 46 (01) :238-250

[2] Absolute number of new lesions on 18F-FDG PET/CT is more predictive of clinical response than SUV changes in metastatic melanoma patients receiving ipilimumab [J].

Anwar, Hoda ;

Sachpekidis, Christos ;

Winkler, Julia ;

Kopp-Schneider, Annette ;

Haberkorn, Uwe ;

Hassel, Jessica C. ;

Dimitrakopoulou-Strauss, Antonia .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2018, 45 (03) :376-383

[3] Novel patterns of response under immunotherapy [J].

Borcoman, E. ;

Kanjanapan, Y. ;

Champiat, S. ;

Kato, S. ;

Servois, V. ;

Kurzrock, R. ;

Goel, S. ;

Bedard, P. ;

Le Tourneau, C. .

ANNALS OF ONCOLOGY, 2019, 30 (03) :385-396

[4]

Borcoman Edith, 2018, Am Soc Clin Oncol Educ Book, V38, P169, DOI 10.1200/EDBK_200643

[5] MGMT promoter methylation status can predict the incidence and outcome of pseudoprogression after concomitant radiochemotherapy in newly diagnosed glioblastoma patients [J].

Brandes, Alba A. ;

Franceschi, Enrico ;

Tosoni, Alicia ;

Blatt, Valeria ;

Pession, Annalisa ;

Tallini, Giovanni ;

Bertorelle, Roberta ;

Bartolini, Stefania ;

Calbucci, Fabio ;

Andreoli, Alvaro ;

Frezza, Giampiero ;

Leonardi, Marco ;

Spagnolli, Federica ;

Ermani, Mario .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (13) :2192-2197

[6] Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas [J].

Brandsma, Dieto ;

Stalpers, Lukas ;

Taal, Walter ;

Sminia, Peter ;

van den Bent, Martinj .

LANCET ONCOLOGY, 2008, 9 (05) :453-461

[7] Radiologic Assessment of Response to Therapy: Comparison of RECIST Versions 1.1 and 1.0 [J].

Chalian, Hamid ;

Toere, Hueseyin Guerkan ;

Horowitz, Jeanne M. ;

Salem, Riad ;

Miller, Frank H. ;

Yaghmai, Vahid .

RADIOGRAPHICS, 2011, 31 (07) :2093-2105

[8]

Chukwueke Ugonma N, 2019, CNS Oncol, V8, pCNS28, DOI 10.2217/cns-2018-0007

[9]

Costelloe CM, 2010, J CANCER, V1, P80

[10]

Dhingra Vandana K, 2015, Indian J Radiol Imaging, V25, P332, DOI 10.4103/0971-3026.169467

← 1 2 3 →