Prime-Boost Vaccination With BNT162b2 Induces High Neutralizing Activity Against SARS-CoV-2 Variants in Naive and COVID-19-Convalescent Individuals

被引：6

作者：

Luczkowiak, Joanna ^{[1
]}

Labiod, Nuria ^{[1
]}

Rivas, Gonzalo ^{[2
]}

Rolo, Marta ^{[2
]}

Lasala, Fatima ^{[1
]}

Lora-Tamayo, Jaime ^{[3
]}

Mancheno-Losa, Mikel ^{[3
]}

Rial, David ^{[2
]}

Perez-Rivilla, Alfredo ^{[2
]}

Folgueira, Maria D. ^{[2
]}

Delgado, Rafael ^{[1
,2
,4
]}

机构：

[1] Inst Invest Hosp 12 Octubre Imas12, Madrid, Spain

[2] Hosp Univ 12 Octubre, Dept Microbiol, Madrid, Spain

[3] Hosp Univ 12 Octubre, Dept Internal Med, Madrid, Spain

[4] Univ Complutense, Sch Med, Madrid, Spain

来源：

OPEN FORUM INFECTIOUS DISEASES | 2021年 / 8卷 / 10期

关键词：

SARS-CoV-2; COVID-19; neutralizing antibodies; vaccines; variants of concern;

D O I：

10.1093/ofid/ofab468

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. The objective of this study was to investigate the neutralizing response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VoC) during coronavirus disease 2019 (COVID-19) convalescence and after vaccination. Methods. COVID-19-convalescent and -naive individuals were tested for neutralizing activity against SARS-CoV-2 VoC Alpha, Beta, Gamma, and Delta at 1 and 7 months postinfection and 4-6 weeks after BNT162b2 vaccination. Results. Vaccination induced a high neutralizing response in naive individuals. Interestingly, vaccination of convalescent patients induced a boosted response that was able to neutralize all VoC at high titers. Conclusions. Vaccination with BNT162b2 induced high levels of neutralization against SARS-CoV-2 VoC in most patients; this is especially beneficial in COVID-19-convalescent individuals.

引用

页数：4

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