Regulation of Bcl-2 family proteins by posttranslational modifications

被引：0

作者：

Kutuk, Ozgur ^{[1
]}

Letai, Anthony ^{[1
]}

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

来源：

CURRENT MOLECULAR MEDICINE | 2008年 / 8卷 / 02期

关键词：

Bcl-2; apoptosis; BH3-only; BAX; BIM; BID; BAD; phosphorylation; kinase; proteosome; MCL-1;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Like many proteins, function and abundance of Bcl-2 family proteins are influenced by posttranslational modifications. These modifications include phosphorylation, proteolytic cleavage, ubiquitination, and proteosomal degradation. These modifications, depending on cellular context and the proteins involved, can result either in a promotion of inhibition of apoptosis. Many of these modifications are governed by the activity of enzymes. As modulation of enzymatic activity can be achieved fairly efficiently using small molecules, understanding the effects of posttranslational modifications may allow for the therapeutic inhibition or promotion of apoptosis.

引用

页码：102 / 118

页数：17

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