Adenosine receptor containing oligomers: Their role in the control of dopamine and glutamate neurotransmission in the brain

被引:60
作者
Ciruela, Francisco [1 ]
Gomez-Soler, Maricel [1 ]
Guidolin, Diego [2 ]
Borroto-Escuela, Dasiel O. [3 ]
Agnati, Luigi F. [4 ]
Fuxe, Kjell [3 ]
Fernandez-Duenas, Victor [1 ]
机构
[1] Univ Barcelona, Unitat Farmacol, Dept Patol & Terapeut Expt, Fac Med, Lhospitalet De Llobregat 08097, Spain
[2] Univ Padua, Dept Human Anat & Physiol, Padua, Italy
[3] Karolinska Inst, Dept Neurosci, Stockholm, Sweden
[4] IRCCS San Camillo, Lido Venezia, Italy
来源
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2011年 / 1808卷 / 05期
关键词
G protein-coupled receptors; Adenosine receptors; Protein-protein interaction; GPCR oligomerization; HIGHER-ORDER OLIGOMERS; PROTEIN-COUPLED RECEPTORS; A(2A) RECEPTORS; A(1) RECEPTOR; D-1; RECEPTORS; METABOTROPIC GLUTAMATE-5; QUANTITATIVE ASSESSMENT; HEPTAHELICAL RECEPTORS; PRESYNAPTIC INHIBITION; CELLULAR-LOCALIZATION;
D O I
10.1016/j.bbamem.2011.02.007
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
While the G protein-coupled receptor (GPCR) oligomerization has been questioned during the last fifteen years, the existence of a multi-receptor complex involving direct receptor-receptor interactions, called receptor oligomers, begins to be widely accepted. Eventually, it has been postulated that oligomers constitute a distinct functional form of the GPCRs with essential receptorial features. Also, it has been proven, under certain circumstances, that the GPCR oligomerization phenomenon is crucial for the receptor biosynthesis, maturation, trafficking, plasma membrane diffusion, and pharmacology and signalling. Adenosine receptors are GPCRs that mediate the physiological functions of adenosine and indeed these receptors do also oligomerize. Accordingly, adenosine receptor oligomers may improve the molecular mechanism by which extracellular adenosine signals are transferred to the G proteins in the process of receptor transduction. Importantly, these adenosine receptor-containing oligomers may allow not only the control of the adenosinergic function but also the fine-tuning modulation of other neurotransmitter systems (i.e. dopaminergic and glutamatergic transmission). Overall, we underscore here recent significant developments based on adenosine receptor oligomerization that are essential for acquiring a better understanding of neurotransmission in the central nervous system under normal and pathological conditions. This article is part of a Special Issue entitled: "Adenosine Receptors". (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码:1245 / 1255
页数:11
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