Immunotherapy of cancer in the era of checkpoint inhibitor

被引:6
作者
Mehmi, Inderjit [1 ]
Hamid, Omid [1 ]
机构
[1] Cedar Sinai Affiliate, Angeles Clin & Res Inst, Los Angeles, CA USA
关键词
Melanoma; cSCC; MCC; Immunotherapy; Checkpoint inhibitors; TIM-3; LAG-3; Cytokines; NSCLC; T-CELLS; IPILIMUMAB; PD-1; CHEMOTHERAPY; BLOCKADE;
D O I
10.1007/s10585-021-10132-9
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Application of immunotherapy has revolutionized treatment of number of malignancies. We present a review of immunotherapy approaches, early-phase data of number of new immunotherapeutic targets in melanoma, cutaneous squamous cell carcinoma, Merkel cell cancer, and non-small cell lung cancer.
引用
收藏
页码:231 / 237
页数:7
相关论文
共 47 条
[1]  
Bodor JN, 2020, 2020 N AM C LUNG CAN
[2]   PREVENTION OF T-CELL ANERGY BY SIGNALING THROUGH THE GAMMA(C) CHAIN OF THE IL-2 RECEPTOR [J].
BOUSSIOTIS, VA ;
BARBER, DL ;
NAKARAI, T ;
FREEMAN, GJ ;
GRIBBEN, JG ;
BERNSTEIN, GM ;
DANDREA, AD ;
RITZ, J ;
NADLER, LM .
SCIENCE, 1994, 266 (5187) :1039-1042
[3]   PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors [J].
Curran, Michael A. ;
Montalvo, Welby ;
Yagita, Hideo ;
Allison, James P. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (09) :4275-4280
[4]   Efficacy and Safety of First-line Avelumab Treatment in Patients With Stage IV Metastatic Merkel Cell Carcinoma A Preplanned Interim Analysis of a Clinical Trial [J].
D'Angelo, Sandra P. ;
Russell, Jeffery ;
Lebbe, Celeste ;
Chmielowski, Bartosz ;
Gambichler, Thilo ;
Grob, Jean-Jacques ;
Kiecker, Felix ;
Rabinowits, Guilherme ;
Terheyden, Patrick ;
Zwiener, Isabella ;
Bajars, Marcis ;
Hennessy, Meliessa ;
Kaufman, Howard L. .
JAMA ONCOLOGY, 2018, 4 (09)
[5]   Tebentafusp: T Cell Redirection for the Treatment of Metastatic Uveal Melanoma [J].
Damato, Bertil E. ;
Dukes, Joseph ;
Goodall, Howard ;
Carvajal, Richard D. .
CANCERS, 2019, 11 (07)
[6]   Phase Ib/II Study of Pembrolizumab and Pegylated-Interferon Alfa-2b in Advanced Melanoma [J].
Davar, Diwakar ;
Wang, Hong ;
Chauvin, Joe-Marc ;
Pagliano, Ornella ;
Fourcade, Julien J. ;
Ka, Mignane ;
Menna, Carmine ;
Rose, Amy ;
Sander, Cindy ;
Borhani, Amir A. ;
Karunamurthy, Arivarasan ;
Tarhini, Ahmad A. ;
Tawbi, Hussein A. ;
Zhao, Qing ;
Moreno, Blanca H. ;
Ebbinghaus, Scott ;
Ibrahim, Nageatte ;
Kirkwood, John M. ;
Zarour, Hassane M. .
JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (35) :3450-+
[7]  
Diab A., 2018, Ann Oncol, V29, pviii442, DOI DOI 10.1093/ANNONC/MDY289.001
[8]   Pushing the accelerator and releasing the brake: A phase I dose escalation study evaluating a LAG-3 fusion protein (eftilagimod alpha), together with pembrolizumab in unresectable or metastatic melanoma. [J].
Eastgate, Melissa A. ;
Atkinson, Victoria ;
Khattak, Muhammad Adnan ;
Roy, Amitesh Chandra ;
Haydon, Andrew Mark ;
Mueller, Christian ;
Dunkelmann, Tina ;
Brignone, Chrystelle ;
Frederic, Triebel .
JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (15)
[9]   Pembrolizumab plus Chemotherapy in Metastatic Non-Small-Cell Lung Cancer [J].
Gandhi, L. ;
Rodriguez-Abreu, D. ;
Gadgeel, S. ;
Esteban, E. ;
Felip, E. ;
De Angelis, F. ;
Domine, M. ;
Clingan, P. ;
Hochmair, M. J. ;
Powell, S. F. ;
Cheng, S. Y. -S. ;
Bischoff, H. G. ;
Peled, N. ;
Grossi, F. ;
Jennens, R. R. ;
Reck, M. ;
Hui, R. ;
Garon, E. B. ;
Boyer, M. ;
Rubio-Viqueira, B. ;
Novello, S. ;
Kurata, T. ;
Gray, J. E. ;
Vida, J. ;
Wei, Z. ;
Yang, J. ;
Raftopoulos, H. ;
Pietanza, M. C. ;
Garassino, M. C. .
NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (22) :2078-2092
[10]   Myeloid Cell-Derived Arginase in Cancer Immune Response [J].
Grzywa, Tomasz M. ;
Sosnowska, Anna ;
Matryba, Pawel ;
Rydzynska, Zuzanna ;
Jasinski, Marcin ;
Nowis, Dominika ;
Golab, Jakub .
FRONTIERS IN IMMUNOLOGY, 2020, 11