Cellulose-based self-healing hydrogel through boronic ester bonds with excellent biocompatibility and conductivity

被引:56
作者
An, Heng [1 ]
Bo, Yunyi [2 ]
Chen, Danyang [1 ]
Wang, Yong [3 ]
Wang, Haijun [1 ]
He, Yingna [2 ]
Qin, Jianglei [1 ,3 ]
机构
[1] Hebei Univ, Coll Chem & Environm Sci, Baoding City 071002, Hebei, Peoples R China
[2] Hebei Univ Chinese Med, Pharmaceut Coll, Hebei Key Lab Chinese Med Res Cardiocerebrovasc D, Shijiazhuang 050200, Hebei, Peoples R China
[3] Hebei Univ, Key Lab Pathogenesis Mech & Control Inflammatory, Baoding City 071002, Hebei, Peoples R China
基金
中国国家自然科学基金;
关键词
ACID-BASED HYDROGELS; HEALABLE HYDROGELS; ADHESIVE HYDROGEL; DRUG-DELIVERY; PH; RELEASE; TOUGH;
D O I
10.1039/c9ra10736c
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Self-healing hydrogels based on degradable resources have developed rapidly in the past decade due to their extensive bioapplications with biosecurity. In this research, a new kind of cellulose-based self-healing hydrogel with bio-degradability is constructed through boronic ester linkage. The carboxyethyl cellulose-graft-phenylboronic acid (CMC-B(OH)(2)) was synthesized through condensation reaction conveniently and then hydrogels were prepared with dynamic boronic ester cross-linking. The chemical structures, microscopic morphologies, mechanical and self-healing properties of the hydrogels were investigated intensively through Fourier transform infrared (FT-IR) spectroscopy, rheological, SEM and tensile testing. The hydrogels formed instantly without any additional catalyst and exhibit excellent self-healing ability with good mechanical properties. Moreover, the hydrogels were applied for controlled release of doxorubicin (DOX center dot HCl) and showed a successive slow release profile. Importantly, the hydrogel exhibited excellent biocompatibility and show potential applications in controlled drug delivery, 3D cell culture and tissue engineering.
引用
收藏
页码:11300 / 11310
页数:11
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