NiH-Catalyzed Migratory Defluorinative Olefin Cross-Coupling: Trifluoromethyl-Substituted Alkenes as Acceptor Olefins to Form gem-Difluoroalkenes

被引：130

作者：

Chen, Fenglin ^{[1
]}

Xu, Xianfeng ^{[1
]}

He, Yuli ^{[1
]}

Huang, Genping ^{[2
,3
]}

Zhu, Shaolin ^{[1
]}

机构：

[1] Nanjing Univ, State Key Lab Coordinat Chem, Jiangsu Key Lab Adv Organ Mat, Chem & Biomed Innovat Ctr ChemBIC,Sch Chem & Chem, Nanjing 210093, Jiangsu, Peoples R China

[2] Tianjin Univ, Sch Sci, Dept Chem, Tianjin 300072, Peoples R China

[3] Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300072, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2020年 / 59卷 / 13期

关键词：

C-H activation; cross-coupling; isomerization; nickel; regioselectivity; C-F; ISOMERIZATION-HYDROBORATION; DIAZO-COMPOUNDS; REMOTE; FUNCTIONALIZATION; HYDROARYLATION; ARYLATION; DIFLUOROOLEFINATION; HYDROSILYLATION; CARBOXYLATION;

D O I：

10.1002/anie.201915840

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a NiH-catalyzed migratory defluorinative coupling between two electronically differentiated olefins. A broad range of unactivated donor olefins can be joined directly to acceptor olefins containing an electron-deficient trifluoromethyl substituent in both intra- and intermolecular fashion to form gem-difluoroalkenes. This migratory coupling shows both site- and chemoselectivity under mild conditions, with the formation of a tertiary or quaternary carbon center.

引用

页码：5398 / 5402

页数：5

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