3D Printing of Regenerated Silk Fibroin and Antibody-Containing Microstructures via Multiphoton Lithography

被引：40

作者：

Dickerson, Matthew B. ^{[1
]}

Dennis, Patrick B. ^{[1
]}

Tondiglia, Vincent P. ^{[1
]}

Nadeau, Lloyd J. ^{[1
]}

Singh, Kristi M. ^{[1
]}

Drummy, Lawrence F. ^{[1
]}

Partlow, Benjamin P. ^{[2
]}

Brown, Dean P. ^{[1
]}

Omenetto, Fiorenzo G. ^{[2
]}

Kaplan, David L. ^{[2
]}

Naik, Rajesh R. ^{[3
]}

机构：

[1] Air Force Res Lab, Mat & Mfg Directorate, Wright Patterson AFB, OH 45433 USA

[2] Tufts Univ, Biomed Engn Dept, Medford, MA 02155 USA

[3] Air Force Res Lab, Human Performance Wing 711, Wright Patterson AFB, OH 45433 USA

来源：

ACS BIOMATERIALS SCIENCE & ENGINEERING | 2017年 / 3卷 / 09期

关键词：

silk; fibroin; multiphoton lithography; hydrogel; IgG; DIRECT-WRITE; CROSS-LINKING; ELECTRONIC DEVICES; DRUG-DELIVERY; PROTEIN; FABRICATION; MICROFABRICATION; SCAFFOLDS; STABILIZATION; HYDROGELS;

D O I：

10.1021/acsbiomaterials.7b00338

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Regenerated silk fibroin, a biopolymer derived from silkworm cocoons, is a versatile material that has been widely explored for a number of applications (e.g., drug delivery, tissue repair, biocompatible electronics substrates, and optics) due to its attractive biochemical properties and processability. Here, we report on the free-form printing of silk-based, 3D microstructures through multiphoton lithography. Utilizing multiphoton lithography in conjunction with specific photoinitiator chemistry and postprint cross-linking, a number of microarchitectures were achieved including self-supporting fibroin arches. Further, the straightforward production of high fidelity and biofunctional protein architectures was enabled through the printing of aqueous fibroin/immunoglobulin solutions.

引用

页码：2064 / 2075

页数：12

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