Natural product biosynthesis moves in vitro

被引：7
作者：
Fecik, Robert A. [1 ]
机构：
[1] Univ Minnesota, Dept Med Chem, Minneapolis, MN 55455 USA
来源：
NATURE CHEMICAL BIOLOGY | 2007年 / 3卷 / 09期
关键词：
D O I：
10.1038/nchembio0907-531
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Heterologous production of natural products in non-native bacteria can be used to increase yields of certain bioactive compounds; however, producing small molecules inside bacteria has numerous limitations. Two reports of the in vitro reconstruction of entire biosynthetic pathways highlight the advantages and challenges of this approach for pathway engineering.
引用
收藏
页码：531 / 532
页数：2
相关论文
共 5 条
  • [1] Terrequinone A biosynthesis through L-tryptophan oxidation, dimerization and bisprenylation
    Balibar, Carl J.
    Howard-Jones, Annaleise R.
    Walsh, Christopher T.
    [J]. NATURE CHEMICAL BIOLOGY, 2007, 3 (09) : 584 - 592
  • [2] Total synthesis of marine natural products without using protecting groups
    Baran, Phil S.
    Maimone, Thomas J.
    Richter, Jeremy M.
    [J]. NATURE, 2007, 446 (7134) : 404 - 408
  • [3] Enzymatic total synthesis of enterocin polyketides
    Cheng, Qian
    Xiang, Longkuan
    Izumikawa, Miho
    Meluzzi, Dario
    Moore, Bradley S.
    [J]. NATURE CHEMICAL BIOLOGY, 2007, 3 (09) : 557 - 558
  • [4] Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics: Logic, machinery, and mechanisms
    Fischbach, Michael A.
    Walsh, Christopher T.
    [J]. CHEMICAL REVIEWS, 2006, 106 (08) : 3468 - 3496
  • [5] Expression of biosynthetic gene clusters in heterologous hosts for natural product production and combinatorial biosynthesis
    Galm, Ute
    Shen, Ben
    [J]. EXPERT OPINION ON DRUG DISCOVERY, 2006, 1 (05) : 409 - 437
1