Pd-Catalyzed Benzylic C-H Amidation with Benzyl Alcohols in Water: A Strategy To Construct Quinazolinones

被引：200
作者：
Hikawa, Hidemasa [1 ]
Ino, Yukari [1 ]
Suzuki, Hideharu [1 ]
Yokoyama, Yuusaku [1 ]
机构：
[1] Toho Univ, Fac Pharmaceut Sci, Funabashi, Chiba 2748510, Japan
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 77卷 / 16期
关键词：
ONE-POT SYNTHESIS; DRY MEDIA; DERIVATIVES; EFFICIENT; RECEPTOR; SYSTEM; 4(3H)-QUINAZOLINONES; CARBONYLATION; CONVERSIONS; CYCLIZATION;
D O I：
10.1021/jo301282n
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel method for the synthesis of 4-phenyl-quinazolinones via a palladium-catalyzed domino reaction of o-aminobenzamides with benzyl alcohols is developed. This protocol involves N-benzylation, benzylic C-H amidation, and dehydrogenation in water, which may play an important role in the smooth generation of the (eta(3)-benzyl)palladium species by activation of the hydroxyl group of the benzyl alcohol.
引用
收藏
页码：7046 / 7051
页数：6
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