microRNA-21 Expression is Elevated in Esophageal Adenocarcinoma After Neoadjuvant Chemotherapy

被引：7

作者：

Ilhan-Mutlu, Ayseguel ^{[1
,2
]}

Tezcan, Guelcin ^{[3
]}

Schoppmann, Sebastian F. ^{[2
,4
]}

Preusser, Matthias ^{[1
,2
]}

Spyridoula, Kommata ^{[5
]}

Karanikas, Georgios ^{[5
]}

Birner, Peter ^{[2
,6
]}

机构：

[1] Med Univ Vienna, Dept Med 1, Div Clin Oncol, Vienna, Austria

[2] Comprehens Canc Ctr Vienna, Gastroesophageal Tumors Unit, Vienna, Austria

[3] Uludag Univ, Fac Med, Dept Med Biol, Bursa, Turkey

[4] Med Univ Vienna, Dept Surg, Vienna, Austria

[5] Med Univ Vienna, Div Nucl Med, Dept Biomed Imaging & Image Guided Therapy, Vienna, Austria

[6] Med Univ Vienna, Dept Pathol, A-1090 Vienna, Austria

来源：

CANCER INVESTIGATION | 2015年 / 33卷 / 06期

关键词：

Esophageal cancer; Adenocarcinoma; microRNA-21; microRNA-148a; Neoadjuvant therapy; FDG-PET-CT; PROGNOSTIC-SIGNIFICANCE; CANCER; INVASION; PROLIFERATION; THERAPY;

D O I：

10.3109/07357907.2015.1024319

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated whether microRNA-21 and microRNA-148a are predictive for neoadjuvant treatment in esophageal adenocarcinoma. Thirty-six patients with neoadjuvant therapy and surgical resection were included. FFPE tissue from biopsy and esophagectomy were analyzed using RT-qPCR. Results were correlated to histological tumor regression, histopathological variables, FDG-PET-CT and survival. MicroRNA-21 was significantly higher in esophagectomies than in corresponding biopsies (p = .027). No association of microRNA-21 or micro RNA-148a expression in tissue specimens with other clinical parameters was present. Although no influence of microRNA-21 and microRNA-148a on the response to neoadjuvant therapy was seen, upregulation of micro RNA-21 might represent an escape mechanism of tumor cells.

引用

页码：246 / 250

页数：5

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