Potentials of human bile acids and their salts in pharmaceutical nano delivery and formulations adjuvants

被引：15

作者：

Kecman, S. ^{[1
]}

Skrbic, R. ^{[2
]}

Cengic, Alma Badnjevic ^{[3
]}

Mooranian, A. ^{[4
]}

Al-Salami, H. ^{[4
]}

Mikov, M. ^{[5
]}

Golocorbin-Kon, S. ^{[6
]}

机构：

[1] Hemofarm Doo, Stada Grp, Banja Luka, Republic Of Srp, Bosnia & Herceg

[2] Univ Banja Luka, Ctr Biomed Res, Fac Med, Banja Luka, Republic Of Srp, Bosnia & Herceg

[3] Cantonal Hosp, Dept Endocrinol, Zenica, Bosnia & Herceg

[4] Curtin Univ, Biotechnol & Drug Dev Res Lab, Sch Pharm, Curtin Hlth Innovat Res Inst, Perth, WA, Australia

[5] Univ Novi Sad, Dept Pharmacol Toxicol & Clin Pharmacol, Fac Med, Novi Sad, Serbia

[6] Univ Novi Sad, Dept Pharm, Fac Med, Novi Sad, Serbia

来源：

TECHNOLOGY AND HEALTH CARE | 2020年 / 28卷 / 03期

基金：

欧盟地平线“2020”;

关键词：

Bile acids; bilosomes; nano-structures; absorption enhancers; drug delivery; IN-VITRO; DRUG-DELIVERY; NASAL ABSORPTION; INSULIN; BILOSOMES; PERMEABILITY; ENHANCEMENT; PEPTIDE; CARRIER;

D O I：

10.3233/THC-191845

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

In the last decade, the attention of the scientific community has been focused on bile acids and their salts as systems for the transportation of drugs; specifically their role as carriers and integration into nanomedicine. Bile acids can play a critical role as drug carriers in the form of chemical conjugates, complexation, mixed micelles formation as well as stabilized bile acid liposomes (bilosomes). The unique molecular structure and interaction of these amphiphilic-steroidal compounds make them an interesting subject of research. This review is based on literature research in order to emphasize the importance of bile acids and their salts as absorption modulators in order to improve therapeutic potentials of low bioavailability drugs.

引用

页码：325 / 335

页数：11

共 40 条

[1] Investigating the potential of employing bilosomes as a novel vesicular carrier for transdermal delivery of tenoxicam
Al-mahallawi, Abdulaziz M.
Abdelbary, Aly A.
Aburahma, Mona H.
[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2015, 485 (1-2) : 329 - 340
[2] Ayogu I. J., 2009, Current Drug Delivery, V6, P415
[3] Baringhaus KH, 1999, J LIPID RES, V40, P2158
[4] Salmon calcitonin-loaded Eudragit® and Eudragit®-PLGA nanoparticles: in vitro and in vivo evaluation
Cetin, Meltem
Aktas, Mustafa Sinan
Vural, Imran
Ozturk, Murat
[J]. JOURNAL OF MICROENCAPSULATION, 2012, 29 (02) : 156 - 166
[5] Enhanced bioavailability of the poorly water-soluble drug fenofibrate by using liposomes containing a bile salt
Chen, Yaping
Lu, Yi
Chen, Jianming
Lai, Jie
Sun, Jing
Hu, Fuqiang
Wu, Wei
[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2009, 376 (1-2) : 153 - 160
[6] Oral immunisation with peptide and protein antigens by formulation in lipid vesicles incorporating bile salts (bilosomes)
Conacher, M
Alexander, J
Brewer, JM
[J]. VACCINE, 2001, 19 (20-22) : 2965 - 2974
[7] Multifaceted applications of bile salts in pharmacy: an emphasis on nanomedicine
Elnaggar, Yosra S. R.
[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE, 2015, 10 : 3955 - 3971
[8] Deoxycholic acid modified-carboxymethyl curdlan conjugate as a novel carrier of epirubicin: In vitro and in vivo studies
Gao, Fuping
Li, Lei
Zhang, Huizhu
Yang, Wenzhi
Chen, Hongli
Zhou, Jing
Zhou, Zhimin
Wang, Yinsong
Cai, Yuanyuan
Li, Xuemin
Liu, Lingrong
Zhang, Qiqing
[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2010, 392 (1-2) : 254 - 260
[9] Biodegradable polymers based on bile acids and potential biomedical applications
Gautrot, J. E.
Zhu, X. X.
[J]. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2006, 17 (10) : 1123 - 1139
[10] NASAL ABSORPTION OF INSULIN - ENHANCEMENT BY HYDROPHOBIC BILE-SALTS
GORDON, GS
MOSES, AC
SILVER, RD
FLIER, JS
CAREY, MC
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (21) : 7419 - 7423

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