Highly effective activation of aryl chlorides for Suzuki coupling in aqueous media using a ferrocene-based Pd(II)-diimine catalyst

被引：19

作者：

Hanhan, Murat Emre ^{[1
]}

Martinez-Manez, Ramon ^{[2
,3
]}

Vicente Ros-Lis, Jose ^{[2
]}

机构：

[1] Zonguldak Karaelmas Univ, Sci & Letters Fac, Dept Chem, TR-67100 Zonguldak, Turkey

[2] Univ Politecn Valencia, Dept Quim, Valencia 46022, Spain

[3] CIBER Bioingn Biomat & Nanomed CIBER BBN, Valencia, Spain

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 19期

关键词：

Suzuki coupling; Green chemistry; Pd(II) complexes; Microwave irradiation; Aryl chlorides; ARYLBORONIC ACIDS; CROSS-COUPLINGS; LIGANDS; MIYAURA; WATER; COMPLEXES; CONVENIENT; HALIDES; SYSTEM; MILD;

D O I：

10.1016/j.tetlet.2012.02.102

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Suzuki coupling of aryl chlorides with boronic acids using a ferrocene-containing Pd(II)-diimine complex as catalyst, in aqueous media, under microwave heating is reported. A small amount of the catalyst (0.1%) was found to be highly effective for coupling unactivated aryl chlorides with boronic acids to form sterically hindered ortho-substituted biaryls. The same catalyst also enabled the coupling of aryl bromides and iodides with various boronic acids in very high yields. The catalyst is air stable and the catalytic reaction can be completed in 15 min. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：2388 / 2391

页数：4

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