More support for high-dose atorvastatin in coronary artery disease

被引:0
作者
Doggrell, SA [1 ]
机构
[1] Univ Auckland, Div Hlth Practice, Auckland 1, New Zealand
关键词
atorvastatin; clinical trials; coronary artery disease; magnetic resonance imaging;
D O I
10.1517/14656566.6.13.2365
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Previous studies have shown that intensive lipid lowering with atorvastatin has advantages over moderate lipid lowering with pravastatin in patients with coronary heart disease. An important question that remains is whether atorvastatin has advantages over other statins per se, or whether it is the dose of atorvastatin that is important. The Treating to New Targets (TNT) study compared atorvastatin 80 and 10 mg/day on clinical end points in patients with stable coronary disease. After a median follow up of 4.9 years, events (death from coronary heart disease, nonfatal myocardial infarction, resuscitation after cardiac arrest, or stroke) had occurred in 8.7% of the high-dose atorvastatin patients compared with 10.9% taking atorvastatin 10 mg/day. A magnetic resonance imaging study that compared the effects of atorvastatin 5 and 20 mg on aortic atherosclerosis showed that there was no effect with atorvastatin 5 mg over 12 months, suggesting prevention of progression, whereas atorvastatin 20 mg produced regression. These studies show that the dose of atorvastatin is important in coronary heart disease, with the more intensive the lipid-lowering, the greater the benefits with atorvastatin.
引用
收藏
页码:2365 / 2368
页数:4
相关论文
共 50 条
[11]   High-Dose Versus Low-Dose Pitavastatin in Japanese Patients With Stable Coronary Artery Disease (REAL-CAD) A Randomized Superiority Trial [J].
Taguchi, Isao ;
Iimuro, Satoshi ;
Iwata, Hiroshi ;
Takashima, Hiroaki ;
Abe, Mitsuru ;
Amiya, Eisuke ;
Ogawa, Takanori ;
Ozaki, Yukio ;
Sakuma, Ichiro ;
Nakagawa, Yoshihisa ;
Hibi, Kiyoshi ;
Hiro, Takafumi ;
Fukumoto, Yoshihiro ;
Hokimoto, Seiji ;
Miyauchi, Katsumi ;
Yamazaki, Tsutomu ;
Ito, Hiroshi ;
Otsuji, Yutaka ;
Kimura, Kazuo ;
Takahashi, Jun ;
Hirayama, Atsushi ;
Yokoi, Hiroyoshi ;
Kitagawa, Kazuo ;
Urabe, Takao ;
Okada, Yasushi ;
Terayama, Yasuo ;
Toyoda, Kazunori ;
Nagao, Takehiko ;
Matsumoto, Masayasu ;
Ohashi, Yasuo ;
Kaneko, Tetsuji ;
Fujita, Retsu ;
Ohtsu, Hiroshi ;
Ogawa, Hisao ;
Daida, Hiroyuki ;
Shimokawa, Hiroaki ;
Saito, Yasushi ;
Kimura, Takeshi ;
Inoue, Teruo ;
Matsuzaki, Masunori ;
Nagai, Ryozo .
CIRCULATION, 2018, 137 (19) :1997-2009
[12]   Anti-inflammatory effects of low- and high-dose atorvastatin therapy in patients with coronary heart disease and rheumatoid arthritis [J].
Tutunov, V. S. ;
Popkova, T. V. ;
Novikova, D. S. ;
Nasonov, E. L. ;
Kukharchuk, V. V. .
CARDIOVASCULAR THERAPY AND PREVENTION, 2008, 7 (05) :43-48
[13]   Effect of APC variant in coronary artery disease and response to atorvastatin therapy [J].
Li, Lifang ;
Zhang, Li ;
Cheng, Zhenfeng ;
Chen, Mengting .
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2016, 9 (07) :7600-7606
[14]   Prevention of pediatric graft coronary artery disease: Atorvastatin [J].
Chin, Clifford ;
Lukito, Sophia S. ;
Shek, Jennifer ;
Bernstein, Daniel ;
Perry, Stanton B. .
PEDIATRIC TRANSPLANTATION, 2008, 12 (04) :442-446
[15]   Cost-effectiveness of high-dose atorvastatin compared with regular dose simvastatin [J].
Lindgren, Peter ;
Graff, Jennifer ;
Olsson, Anders G. ;
Pedersen, Terje J. ;
Jonsson, Bengt .
EUROPEAN HEART JOURNAL, 2007, 28 (12) :1448-1453
[16]   Fibrates and high-dose statins to prevent coronary heart disease events [J].
Jones P.H. .
Current Cardiology Reports, 1999, 1 (3) :223-224
[17]   Meta-analysis of the role of high-dose statins administered prior to percutaneous coronary intervention in reducing major adverse cardiac events in patients with coronary artery disease [J].
Hao, Pan-Pan ;
Chen, Yu-Guo ;
Wang, Jia-Li ;
Ji, Wen-Qing ;
Xue, Li ;
Liu, Xiang-Hong ;
Wang, Xing-Li ;
Zhang, Yun .
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2010, 37 (04) :496-500
[18]   Effect of atorvastatin on serum omentin-1 in patients with coronary artery disease [J].
Chen, Qianqian ;
Shang, Xingchen ;
Yuan, Meng ;
Liang, Lining ;
Zhong, Xia .
CORONARY ARTERY DISEASE, 2017, 28 (01) :44-51
[19]   Zhibitai and low-dose atorvastatin reduce blood lipids and inflammation in patients with coronary artery disease [J].
Zhao, Yuhong ;
Peng, Ran ;
Zhao, Wang ;
Liu, Qiong ;
Guo, Yuan ;
Zhao, Shuiping ;
Xu, Danyan .
MEDICINE, 2017, 96 (07)
[20]   Multimodality imaging in coronary artery disease ''The more the better?'' [J].
Greulich, Simon ;
Sechtem, Udo .
COR ET VASA, 2015, 57 (06) :E462-E469