Monitoring Growth and Antibiotic Susceptibility of Escherichia coli with Photoluminescence Emitting Semiconductor Biochips

被引：0

作者：

Nazemi, Elnaz ^{[1
]}

Hassen, Walid M. ^{[1
]}

Frost, Eric H. ^{[1
,2
]}

Dubowski, Jan J. ^{[1
]}

机构：

[1] Univ Sherbrooke, CNRS UMI 3463, 3IT, Lab Quantum Semicond & Photon Based BioNanotechno, 3000,Blvd Univ, Sherbrooke, PQ J1K 0A5, Canada

[2] Univ Sherbrooke, Fac Med & Hlth Sci, Dept Microbiol & Infectiol, 3001,12th Ave North, Sherbrooke, PQ J1H 5N4, Canada

来源：

BIOSENSORS 2016 | 2017年 / 27卷

关键词：

Escherichia coli; Antibiotic susceptibility; Quantum semiconductors; Photoluminiscence; Photocorrosion; GaAs/AlGaAs heterojunction;

D O I：

10.1016/j.protcy.2017.04.104

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Growth and antibiotic sensitivity of Escherichia coli were evaluated with an innovative method based on photocorrosion of biofunctionalized GaAs/AlGaAs quantum well (QW) biochips. The formation of surface oxides and dissolution of a limited thickness GaAs cap material results in the appearance of a characteristic maximum in a time-dependent plot of the photoluminescence (PL) emitting biochip. A position of the PL maximum depends on the electrostatic interaction between bacteria and the biochip surface, and it becomes delayed with increasing concentration of bacteria growing on the biochip surface. We demonstrate detection of the bacteria reaction to antibiotics within less than 3 hours. (C) 2017 The Authors. Published by Elsevier Ltd.

引用

页码：244 / 245

页数：2

共 2 条

[1] Photonic biosensor based on photocorrosion of GaAs/AlGaAs quantum heterostructures for detection of Legionella pneumophila [J].