Improving nuclear morphometry imaging with real-time and low-cost line-scanning confocal microendoscope

被引：6

作者：

Tang, Yubo ^{[1
]}

Kortum, Alex ^{[1
]}

Vohra, Imran ^{[1
]}

Othman, Mohamed ^{[2
]}

Dhingra, Sadhna ^{[2
]}

Mansour, Nabil ^{[2
]}

Carns, Jennifer ^{[1
]}

Anandasabapathy, Sharmila ^{[2
]}

Richards-Kortum, Rebecca ^{[1
]}

机构：

[1] Rice Univ, Bioengn, Houston, TX 77005 USA

[2] Baylor Coll Med, Houston, TX 77030 USA

来源：

OPTICS LETTERS | 2019年 / 44卷 / 03期

基金：

美国国家科学基金会;

关键词：

Associated feature - Confocal microendoscopes - Disease progression - Fluorescence microendoscope - Minimally invasive - Nuclear morphometry - Optical sectioning - Subcellular resolution;

D O I：

10.1364/OL.44.000654

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Fiber-optic endomicroscopy is a minimally invasive tool to probe disease progression with subcellular resolution. In this Letter, we demonstrate a low-cost and compact fluorescence microendoscope capable of line-scanning confocal imaging by synchronizing a digital light projector with a CMOS camera. We present the digital aperture design to enable real-time confocal imaging, and we implement parallel illumination to improve the optical sectioning performance. Furthermore, we show that the confocal microendoscope can enhance visualization of disease-associated features when imaging highly scattering esophageal specimens. (C) 2019 Optical Society of America

引用

页码：654 / 657

页数：4

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