Flavin metamorphosis: cofactor transformation through prenylation

被引:34
作者
Leys, David [1 ]
机构
[1] Univ Manchester, Manchester Inst Biotechnol, 131 Princess St, Manchester M1 7DN, Lancs, England
基金
欧洲研究理事会; 英国生物技术与生命科学研究理事会;
关键词
FERULIC ACID DECARBOXYLASE; OXIDATIVE MATURATION; CRYSTAL-STRUCTURE; ESCHERICHIA-COLI; BIOSYNTHESIS; ENZYME; UBIX; CARBOXYLATION; MECHANISM; PHENYLPHOSPHATE;
D O I
10.1016/j.cbpa.2018.09.024
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Prenylated flavin (prFMN) is a recently discovered cofactor that underpins catalysis in the ubiquitous microbial UbiDX system. UbiX acts as a flavin prenyltransferase while UbiD is a prFMN-dependent reversible (de)carboxylase. The extensive modification of flavin by prenylation, and the consecutive oxidation to the prFMN(iminium) azomethine ylide, leads to cofactor metamorphosis. While prFMN is no longer able to perform N5-based classical flavin chemistry, it is capable of forming cycloadducts with dipolarophiles, long-lived C4a-based radical species as well as undergoing extensive light driven isomerization. An ever-expanding range of distinct prFMN forms hints at the possibility of novel prFMN driven biochemistry yet to be discovered.
引用
收藏
页码:117 / 125
页数:9
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