Enhancing cellular sulfane sulfur through β-glycosidase-activated persulfide donors: mechanistic insights and oxidative stress mitigation

被引：10
作者：
Bora, Prerona [1 ]
Sathian, Manjima B. [1 ]
Chakrapani, Harinath [1 ]
机构：
[1] Indian Inst Sci Educ & Res Pune, Dept Chem, Pune 411008, Maharashtra, India
来源：
CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 18期
关键词：
FLUORESCENT-PROBES; CARBONYL SULFIDE; HYDROGEN-SULFIDE; DRUG-DELIVERY; GLUCOSIDASE;
D O I：
10.1039/d1cc07162a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Sulfane sulfur species such as persulfides and polysulfides along with hydrogen sulfide protect cells from oxidative stress and are key members of the cellular antioxidant pool. Here, we report perthiocarbamate-based prodrugs that are cleaved by beta-glycosidases to produce persulfide and relatively innocuous byproducts. The beta-glucosidase-activated persulfide donor enhances cellular sulfane sulfur and protects cells against lethality induced by elevated reactive oxygen species (ROS).
引用
收藏
页码：2987 / 2990
页数：4
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