Microstructure and Genetic Polymorphisms: Role in Motor Rehabilitation After Subcortical Stroke

被引:1
作者
Liu, Jingchun [1 ,2 ]
Wang, Caihong [3 ]
机构
[1] Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin, Peoples R China
[2] Tianjin Med Univ, Gen Hosp, Tianjin Key Lab Funct Imaging, Tianjin, Peoples R China
[3] Zhengzhou Univ, Affiliated Hosp 1, Key Lab Funct Magnet Resonance Imaging & Mol Imag, Dept MRI, Zhengzhou, Peoples R China
来源
FRONTIERS IN AGING NEUROSCIENCE | 2022年 / 14卷
关键词
cerebral infarction; corticospinal tract (CST); genetic polymorphisms; motor; rehabilitation; CORTICOSPINAL TRACT INJURY; NEUROTROPHIC FACTOR LEVELS; VAL66MET POLYMORPHISM; BDNF; ISCHEMIA; ASSOCIATION; RECOVERY; NEUROPLASTICITY; PROGNOSIS; VARIANT;
D O I
10.3389/fnagi.2022.813756
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background and Purpose: Motor deficits are the most common disability after stroke, and early prediction of motor outcomes is critical for guiding the choice of early interventions. Two main factors that may impact the response to rehabilitation are variations in the microstructure of the affected corticospinal tract (CST) and genetic polymorphisms in brain-derived neurotrophic factor (BDNF). The purpose of this article was to review the role of these factors in stroke recovery, which will be useful for constructing a predictive model of rehabilitation outcomes.Summary of Review: We review the microstructure of the CST, including its origins in the primary motor area (M1), primary sensory area (S1), premotor cortex (PMC), and supplementary motor area (SMA). Damage to these fibers is disease-causing and can directly affect rehabilitation after subcortical stroke. BDNF polymorphisms are not disease-causing but can indirectly affect neuroplasticity and thus motor recovery. Both factors are known to be correlated with motor recovery. Further work is needed using large longitudinal patient samples and animal experiments to better establish the role of these two factors in stroke rehabilitation.Conclusions: Microstructure and genetic polymorphisms should be considered possible predictors or covariates in studies investigating motor recovery after subcortical stroke. Future predictive models of stroke recovery will likely include a combination of structural and genetic factors to allow precise individualization of stroke rehabilitation strategies.
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相关论文
共 61 条
[1]   Association of Brain-derived neurotrophic factor gene polymorphisms with body mass index: A systematic review and meta-analysis [J].
Akbarian, Shahab-Aldin ;
Salehi-Abargouei, Amin ;
Pourmasoumi, Makan ;
Kelishadi, Roya ;
Nikpour, Parvaneh ;
Heidari-Beni, Motahar .
ADVANCES IN MEDICAL SCIENCES, 2018, 63 (01) :43-56
[2]   Genetics of stroke recovery: BDNF val66met polymorphism in stroke recovery and its interaction with aging [J].
Balkaya, Mustafa ;
Cho, Sunghee .
NEUROBIOLOGY OF DISEASE, 2019, 126 :36-46
[3]   Post-stroke recovery: the role of activity-dependent release of brain-derived neurotrophic factor [J].
Berretta, Antonio ;
Tzeng, Yu-Chieh ;
Clarkson, Andrew N. .
EXPERT REVIEW OF NEUROTHERAPEUTICS, 2014, 14 (11) :1335-1344
[4]   Brain-derived neurotrophic factor [J].
Binder, DK ;
Scharfman, HE .
GROWTH FACTORS, 2004, 22 (03) :123-131
[5]   Genetic Variation and Neuroplasticity: Role in Rehabilitation After Stroke [J].
Campbell Stewart, Jill ;
Cramer, Steven C. .
JOURNAL OF NEUROLOGIC PHYSICAL THERAPY, 2017, 41 (03) :S17-S23
[6]   Association Between Brain-Derived Neurotrophic Factor Genotype and Upper Extremity Motor Outcome After Stroke [J].
Chang, Won Hyuk ;
Park, Eunhee ;
Lee, Jungsoo ;
Lee, Ahee ;
Kim, Yun-Hee .
STROKE, 2017, 48 (06) :1457-1462
[7]   Factors influencing the response to high-frequency repetitive transcranial magnetic stimulation in patients with subacute stroke [J].
Chang, Won Hyuk ;
Uhm, Kyeong Eun ;
Shin, Yong-Il ;
Pascual-Leone, Alvaro ;
Kim, Yun-Hee .
RESTORATIVE NEUROLOGY AND NEUROSCIENCE, 2016, 34 (05) :747-755
[8]   Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior [J].
Chen, Zhe-Yu ;
Jing, Deqiang ;
Bath, Kevin G. ;
Ieraci, Alessandro ;
Khan, Tanvir ;
Siao, Chia-Jen ;
Herrera, Daniel G. ;
Toth, Miklos ;
Yang, Chingwen ;
McEwen, Bruce S. ;
Hempstead, Barbara L. ;
Lee, Francis S. .
SCIENCE, 2006, 314 (5796) :140-143
[9]   Ischemic brain damage in mice after selectively modifying BDNF or NT4 gene expression [J].
Endres, M ;
Fan, GP ;
Hirt, L ;
Fujii, M ;
Matsushita, K ;
Liu, X ;
Jaenisch, R ;
Moskowitz, MA .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2000, 20 (01) :139-144
[10]  
Ferrer I, 2001, ACTA NEUROPATHOL, V101, P229