Animal models and vaccines for SARS-CoV infection

被引：110

作者：

Roberts, Anjeanette ^{[1
]}

Lamirande, Elaine W. ^{[1
]}

Vogel, Leatrice ^{[1
]}

Jackson, Jadon P. ^{[1
]}

Paddock, Christopher D. ^{[2
]}

Guarner, Jeannette ^{[2
]}

Zaki, Sherif R. ^{[2
]}

Sheahan, Timothy ^{[3
,4
]}

Baric, Ralph ^{[3
,4
]}

Subbarao, Kanta ^{[1
]}

机构：

[1] NIH, NIAID, Infect Dis Lab, Bethesda, MD 20892 USA

[2] Ctr Dis Control & Prevent, Infect Dis Pathol Activity, Atlanta, GA USA

[3] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA

[4] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC USA

来源：

VIRUS RESEARCH | 2008年 / 133卷 / 01期

关键词：

SARS coronavirus; BALB/c; C57BL/6; 129S6; mice; hamsters; ferrets; non-human primates; vaccines; FIPV; enhanced disease; urbani; HKU-39849; Frankfurt; 1; GD03T0013;

D O I：

10.1016/j.virusres.2007.03.025

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We summarize findings of SARS-CoV infections in several animal models each of which support viral replication in lungs accompanied by histopathological changes and/or clinical signs of illness to varying degrees. New findings are reported on SARS-CoV replication and associated pathology in two additional strains (C57BL/16 and 129S6) of aged mice. We also provide new comparative data on viral replication and associated pathology following infection of golden Syrian hamsters with various SARS-CoV strains and report the levels of neutralizing antibody titers following these infections and the cross-protective efficacy of infection with these strains in protecting against heterologous challenge. Finally, we summarize findings of a variety of vaccine approaches and discuss the available in vitro and in vivo data addressing the potential for disease enhancement following re-infection in animals previously vaccinated against or infected with SARS-CoV. Published by Elsevier B.V.

引用

页码：20 / 32

页数：13

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