Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) - classification, diagnosis and management: review of the EAACI/ENDA and GA2LEN/HANNA

被引：342

作者：

Kowalski, M. L. ^{[1
]}

Makowska, J. S.

Blanca, M. ^{[2
]}

Bavbek, S. ^{[3
]}

Bochenek, G. ^{[4
]}

Bousquet, J. ^{[5
,6
]}

Bousquet, P. ^{[5
,7
]}

Celik, G. ^{[3
]}

Demoly, P. ^{[8
]}

Gomes, E. R. ^{[9
]}

Nizankowska-Mogilnicka, E. ^{[4
]}

Romano, A. ^{[10
]}

Sanchez-Borges, M. ^{[11
]}

Sanz, M. ^{[12
]}

Torres, M. J. ^{[2
]}

De Weck, A. ^{[12
]}

Szczeklik, A. ^{[13
]}

Brockow, K. ^{[14
,15
]}

机构：

[1] Med Univ Lodz, Fac Med, Dept Immunol Rheumatol & Allergy, PL-92213 Lodz, Poland

[2] Carlos Haya Hosp, Malaga, Spain

[3] Ankara Univ, Sch Med, Dept Allergy, TR-06100 Ankara, Turkey

[4] Jagiellonian Univ, Dept Resp Dis, Krakow, Poland

[5] CHU Montpellier, Montpellier, France

[6] INSERM, U780, Montpellier, France

[7] CHU Nimes, GHU Caremeau, BESPIM, F-30029 Nimes, France

[8] Univ Hosp, Hop Arnaud Villeneuve, INSERM U657, Montpellier, France

[9] Hosp Pediat Maria Pia, Dept Allergy, Oporto, Portugal

[10] USCS Allergy Unit, Dept Internal Med & Geriatr, Rome, Italy

[11] Ctr Med Docente La Trinidad, Dept Allergy & Immunol, Caracas, Venezuela

[12] Univ Navarra Clin, Dept Allergy & Clin Immunol, Pamplona, Spain

[13] Jagiellonian Univ, Dept Internal Med, Krakow, Poland

[14] Tech Univ Munich, Dept Dermatol & Allergol Biederstein, Helmholtz Zentrum Munchen TUM, Munich, Germany

[15] Tech Univ Munich, Div Environm Dermatol & Allergol, Helmholtz Zentrum Munchen TUM, Munich, Germany

来源：

ALLERGY | 2011年 / 66卷 / 07期

关键词：

aspirin hypersensitivity; drug allergy; nonsteroidal anti-inflammatory drugs; TOXIC EPIDERMAL NECROLYSIS; PERIPHERAL-BLOOD LEUKOCYTES; STEVENS-JOHNSON-SYNDROME; CHRONIC IDIOPATHIC URTICARIA; ORAL ASPIRIN CHALLENGES; IN-VITRO DIAGNOSIS; BASOPHIL ACTIVATION; PROVOCATION TESTS; COX-2; INHIBITORS; INTERSTITIAL NEPHRITIS;

D O I：

10.1111/j.1398-9995.2011.02557.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

P>Nonsteroidal anti-inflammatory drugs (NSAIDs) are responsible for 21-25% of reported adverse drug events which include immunological and nonimmunological hypersensitivity reactions. This study presents up-to-date information on pathomechanisms, clinical spectrum, diagnostic tools and management of hypersensitivity reactions to NSAIDs. Clinically, NSAID hypersensitivity is particularly manifested by bronchial asthma, rhinosinusitis, anaphylaxis or urticaria and variety of late cutaneous and organ-specific reactions. Diagnosis of hypersensitivity to a NSAID includes understanding of the underlying mechanism and is necessary for prevention and management. A stepwise approach to the diagnosis of hypersensitivity to NSAIDs is proposed, including clinical history, in vitro testing and/or provocation test with a culprit or alternative drug depending on the type of the reaction. The diagnostic process should result in providing the patient with written information both on forbidden and on alternative drugs.

引用

页码：818 / 829

页数：12

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