Structure-Activity Relationship of 4,6-Disubstituted Pyrimidines as EGFR and VEGFR-2 Tyrosine Kinase Inhibitors

被引：2
作者：
Song, Jiho [1 ]
Lee, Jung Wook [1 ]
Chung, Shin Hyuck [1 ]
Wenas, Michelle A. [1 ]
Min, Kyung Hoon [1 ]
机构：
[1] Chung Ang Univ, Coll Pharm, Seoul 06974, South Korea
来源：
BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2017年 / 38卷 / 11期
基金：
新加坡国家研究基金会;
关键词：
EGFR; VEGFR-2; Tyrosine kinase inhibitors; Pyrimidine; GROWTH-FACTOR RECEPTOR; BEVACIZUMAB; ERLOTINIB; CANCER; RESISTANCE; THERAPY; CELL;
D O I：
10.1002/bkcs.11278
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
[No abstract available]
引用
收藏
页码：1255 / 1256
页数：2
相关论文
共 50 条
  • [31] Modeling and Interpretability Study of the Structure-Activity Relationship for Multigeneration EGFR Inhibitors
    Sun, Zhiqi
    Huo, Donghui
    Guo, Jiangyu
    Yan, Aixia
    ACS OMEGA, 2025, 10 (11): : 11176 - 11187
  • [32] ANTI-ANDROGENIC, ANTI-PROSTATE CANCER ACTIVITIES AND EGFR, VEGFR-2 KINASE INHIBITORS OF SOME STEROIDAL DERIVATIVES
    Abdulla, M. M.
    Amr, A. El-Galil E.
    Al-Omar, M. A.
    Hussain, A. A.
    Amer, M. S.
    DIGEST JOURNAL OF NANOMATERIALS AND BIOSTRUCTURES, 2014, 9 (02) : 609 - 624
  • [33] Design, synthesis and biological evaluation of novel 4-anilinoquinazoline derivatives as hypoxia-selective EGFR and VEGFR-2 dual inhibitors
    Wei, Huiqiang
    Duan, Yuqing
    Gou, Wenfeng
    Cui, Jie
    Ning, Hongxin
    Li, Deguan
    Qin, Yong
    Liu, Qiang
    Li, Yiliang
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 181
  • [34] Quantitative structure activity relationship and molecular simulations for the exploration of natural potent VEGFR-2 inhibitors: an in silico anti-angiogenic study
    Sharma, Neha
    Sharma, Mala
    Rahman, Qazi Inamur
    Akhtar, Salman
    Muddassir, Mohd
    JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2021, 39 (08) : 2806 - 2823
  • [35] Targeting Receptor Tyrosine Kinase VEGFR-2 in Hepatocellular Cancer: Rational Design, Synthesis and Biological Evaluation of 1,2-Disubstituted Benzimidazoles
    Abdel-Mohsen, Heba T.
    Abdullaziz, Mona A.
    El Kerdawy, Ahmed M.
    Ragab, Fatma A. F.
    Flanagan, Keith J.
    Mahmoud, Abeer E. E.
    Ali, Mamdouh M.
    El Diwani, Hoda, I
    Senge, Mathias O.
    MOLECULES, 2020, 25 (04):
  • [36] Anti-Angiogenic Therapy: Strategies to Develop Potent VEGFR-2 Tyrosine Kinase Inhibitors and Future Prospect
    Shi, Leilei
    Zhou, Jianfeng
    Wu, Jifeng
    Shen, Yuemao
    Li, Xun
    CURRENT MEDICINAL CHEMISTRY, 2016, 23 (10) : 1000 - 1040
  • [37] Design and discovery of 4-anilinoquinazoline ureas as multikinase inhibitors targeting BRAF, VEGFR-2 and EGFR
    Zhang, Qingwen
    Diao, Yuanyuan
    Wang, Fei
    Fu, Ying
    Tang, Fei
    You, Qidong
    Zhou, Houyuan
    MEDCHEMCOMM, 2013, 4 (06) : 979 - 986
  • [38] Structure-activity relationship studies of the lipophilic tail region of sphingosine kinase 2 inhibitors
    Congdon, Molly D.
    Childress, Elizabeth S.
    Patwardhan, Neeraj N.
    Gumkowski, James
    Morris, Emily A.
    Kharel, Yugesh
    Lynch, Kevin R.
    Santos, Webster L.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (21) : 4956 - 4960
  • [39] Quantitative Structure-Activity Relationship Analysis of 4(3H)-Quinazolone Derivatives as Tyrosine Kinase Inhibitors by Multiple Linear Regression
    Srivastava, Vikas
    Sinha, Deepa
    Tiwari, Anjani K.
    Sharma, Himanshu
    Sharma, Raj Bala
    Singh, Vinay K.
    Mishra, Anil K.
    CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS, 2010, 25 (05) : 559 - 562
  • [40] New insights in the structure-activity relationships of 2-phenylamino-substituted benzothiopyrano[4,3-d]pyrimidines as kinase inhibitors
    Salerno, Silvia
    Garcia-Argaez, Aida Nelly
    Barresi, Elisabetta
    Taliani, Sabrina
    Simorini, Francesca
    La Motta, Concettina
    Amendola, Giorgio
    Tomassi, Stefano
    Cosconati, Sandro
    Novellino, Ettore
    Da Settimo, Federico
    Marini, Anna Maria
    Dalla Via, Lisa
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 150 : 446 - 456
12345