Antigenic profile of avian H5N1 viruses in Asia from 2002 to 2007

被引：95

作者：

Wu, Wai Lan ^{[1
]}

Chen, Yixin ^{[3
,4
]}

Wang, Pui ^{[1
]}

Song, Wenjun ^{[1
]}

Lau, Siu-Yang ^{[1
]}

Rayner, Jane M. ^{[1
]}

Smith, Gavin J. D. ^{[1
]}

Webster, Robert G. ^{[5
]}

Peiris, J. S. Malik ^{[1
]}

Lin, Tianwei ^{[1
,4
]}

Xia, Ningshao ^{[3
,4
]}

Guan, Yi ^{[1
,2
]}

Chen, Honglin ^{[1
,2
]}

机构：

[1] Univ Hong Kong, State Key Lab Emerging Infect Dis, Dept Microbiol, 21 Sassoon Rd, Hong Kong, Hong Kong, Peoples R China

[2] Shantou Univ, Int Inst Infect & Immun, Shantou, Peoples R China

[3] Xiamen Univ, Natl Inst Diagnost & Vaccine Dev Infect Dis, Xiamen, Peoples R China

[4] Xiamen Univ, Sch Life Sci, Xiamen, Peoples R China

[5] St Jude Childrens Res Hosp, Div Virol, Dept Infect Dis, Memphis, TN 38105 USA

来源：

JOURNAL OF VIROLOGY | 2008年 / 82卷 / 04期

关键词：

D O I：

10.1128/JVI.02256-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Antigenic profiles of post-2002 H5N1 viruses representing major genetic clades and various geographic sources were investigated using a panel of 17 monoclonal antibodies raised from five H5N1 strains. Four antigenic groups from seven clades of H5N1 virus were distinguished and characterized based on their cross-reactivity to the monoclonal antibodies in hemagglutination inhibition and cell-based neutralization assays. Genetic polymorphisms associated with the variation of antigenicity of H5N1 strains were identified and further verified in antigenic analysis with recombinant H5N1 viruses carrying specific mutations in the hemagglutinin protein. Modification of some of these genetic variations produced marked improvement to the immunogenicity and cross-reactivity of H5N1 strains in assays utilizing monoclonal antibodies and ferret antisera raised against clade 1 and 2 H5N1 viruses, suggesting that these sites represent antigenically significant amino acids. These results provide a comprehensive antigenic profile for H5N1 virus strains circulating in recent years and will facilitate the recognition of emerging antigenic variants of H5N1 virus and aid in the selection of vaccine strains.

引用

页码：1798 / 1807

页数：10

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