Suicide associated with COVID-19 infection: an immunological point of view

被引：0

作者：

Choi, M. J. ^{[1
]}

Yang, J. W. ^{[2
]}

Lee, S. ^{[3
,4
,5
]}

Kim, J. Y. ^{[1
]}

Oh, J. W. ^{[5
]}

Lee, J. ^{[13
]}

Stubbs, B. ^{[6
,7
,8
]}

Lee, K. H. ^{[9
]}

Koyanagi, A. ^{[10
,11
]}

Hong, S. H. ^{[12
]}

Ghayda, R. A. ^{[13
]}

Hwang, J. ^{[14
]}

Dragioti, E. ^{[15
,16
]}

Jacob, L. ^{[10
,17
]}

Carvalho, A. F. ^{[18
,19
]}

Radua, J. ^{[20
,21
,22
,23
]}

Thompson, T. ^{[24
]}

Smith, L. ^{[25
]}

Fornaro, M. ^{[26
]}

Stickley, A. ^{[27
,28
]}

Bettac, E. L. ^{[29
]}

Han, Y. J. ^{[30
]}

Kronbichler, A. ^{[31
]}

Yon, D. K. ^{[32
]}

Lee, S. W. ^{[33
]}

Shin, J., I ^{[9
]}

Lee, E. ^{[3
,4
]}

Solmi, M. ^{[34
,35
,36
]}

机构：

[1] Yonsei Univ, Coll Med, Seoul, South Korea

[2] Yonsei Univ, Dept Internal Med, Wonju Coll Med, Wonju, South Korea

[3] Dept Psychiat, Seoul, South Korea

[4] Inst Behav Sci Med, Seoul, South Korea

[5] Yonsei Univ, Yongin Severance Hosp, Dept Psychiat, Coll Med, Yongin, South Korea

[6] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England

[7] South London & Maudsley NHS Fdn Trust, Denmark Hill, London, England

[8] Anglia Ruskin Univ, Fac Hlth Social Care & Educ, Chelmsford, Essex, England

[9] Yonsei Univ, Dept Pediat, Coll Med, Seoul, South Korea

[10] Univ Barcelona, Parc Sanitari St Joan de Deu CIBERSAM, Fundacio St Joan de Deu, Barcelona, Spain

[11] ICREA, Barcelona, Spain

[12] Yonsei Univ, Severance Hosp, Coll Med, Seoul, South Korea

[13] Case Western Reserve Univ, Univ Hosp, Urol Inst, Cleveland, OH 44106 USA

[14] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[15] Linkoping Univ, Pain & Rehabil Ctr, Linkoping, Sweden

[16] Linkoping Univ, Dept Med & Hlth Sci, Linkoping, Sweden

[17] Univ Versailles St Quentin En Yvelines, Fac Med, Versailles, France

[18] Ctr Addict & Mental Hlth CAMH, Toronto, ON, Canada

[19] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

[20] Inst Invest Biomed August Pi i Sunyer IDIBAPS, Barcelona, Spain

[21] Mental Hlth Res Networking Ctr CIBERSAM, Barcelona, Spain

[22] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England

[23] Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Solna, Sweden

[24] Univ Greenwich, Sch Human Sci, London, England

[25] Anglia Ruskin Univ, Cambridge Ctr Sport & Exercise Sci, Cambridge, England

[26] Univ Naples Federico II, Dept Neurosci Reprod Sci & Dent, Naples, Italy

[27] Natl Ctr Neurol & Psychiat, Natl Inst Mental Hlth, Dept Prevent Intervent Psychiat Disorders, Kodaira, Tokyo, Japan

[28] Sodertorn Univ, Stockholm Ctr Hlth & Social Change SCOHOST, Huddinge, Sweden

[29] Washington State Univ Vancouver, Dept Psychol, Vancouver, WA USA

[30] Inje Univ, Haeundae Paik Hosp, Hosp Med Ctr, Dept Pediat,Coll Med, Busan, South Korea

[31] Med Univ Innsbruck, Dept Internal Med Nephrol & Hypertens 4, Innsbruck, Austria

[32] Seoul Natl Univ, Coll Med, Seoul Natl Univ Hosp, Dept Pediat, Seoul, South Korea

[33] Sejong Univ, Dept Data Sci, Coll Software Convergence, Seoul, South Korea

[34] Univ Ottawa, Dept Psychiat, Ottawa, ON, Canada

[35] Ottawa Hosp, Dept Mental Hlth, Ottawa, ON, Canada

[36] Univ Ottawa, Ottawa Hosp Res Inst OHRI, Clin Epidemiol Program, Ottawa, ON, Canada

来源：

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES | 2021年 / 25卷 / 20期

关键词：

COVID-19; Suicide; Infection; Inflammation; Cytokine; QUINOLINIC ACID; PROINFLAMMATORY CYTOKINES; CEREBROSPINAL-FLUID; INTERFERON-ALPHA; EXPRESSION; DEPRESSION; ATTEMPTERS; RECEPTOR; SEROPOSITIVITY; METAANALYSIS;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

OBJECTIVE: Coronavirus disease 2019 (COVID-19) is a pandemic and leading cause of death. Beyond the deaths directly caused by the virus and the suicides related to the psychological response to the dramatic changes as socioeconomic related to the pandemic, there might also be suicides related to the inflammatory responses of the infection. Infection induces inflammation as a cytokine storm, and there is an increasing number of studies that report a relationship between infection and suicide. MATERIALS AND METHODS: We searched the World Health Organization status report and the PubMed database for keywords (COVID-19, suicide, infection, inflammation, cytokines), and reviewed five cytokine pathways between suicide and inflammation using two meta-analyses and two observational studies starting from November 31, 2020, focusing on the relationship between suicide and inflammation by infection. First, we discussed existing evidence explaining the relationship between suicidal behaviors and inflammation. Second, we summarized the inflammatory features found in COVID-19 patients. Finally, we highlight the potential for these factors to affect the risk of suicide in COVID-19 patients. RESULTS: Patients infected with COVID-19 have high amounts of IL-1 beta, IFN-gamma, IP10, and MCP1, which may lead to Th1 cell response activation. Also, Th2 cytokines (e.g., IL-4 and IL-10) were increased in COVID-19 infection. In COVID-19 patients, neurological conditions, like headache, dizziness, ataxia, seizures, and others have been observed. CONCLUSIONS: COVID-19 pandemic can serve as a significant environmental factor contributing directly to increased suicide risk; the role of inflammation by an infection should not be overlooked.

引用

页码：6397 / 6407

页数：11

共 83 条

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