It takes nerve to dampen inflammation

被引:77
作者
Metz, CN [1 ]
Tracey, KJ [1 ]
机构
[1] Herman & Susan Merinoff Ctr Patient Oriented Res, Inst Med Res N Shore LIJ, Manhasset, NY 11021 USA
关键词
D O I
10.1038/ni0805-756
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Stimulation of the vagus nerve via the alpha 7 nicotinic acetylcholine receptor can dampen macrophage function. This anti-inflammatory pathway seems to signal through the Jak2-STAT3 pathway.
引用
收藏
页码:756 / 757
页数:3
相关论文
共 12 条
[11]   Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation [J].
Wang, H ;
Yu, M ;
Ochani, M ;
Amella, CA ;
Tanovic, M ;
Susarla, S ;
Li, JH ;
Wang, HC ;
Yang, H ;
Ulloa, L ;
Al-Abed, Y ;
Czura, CJ ;
Tracey, KJ .
NATURE, 2003, 421 (6921) :384-388
[12]  
WAXMAN SG, 2003, CLIN NEUROANATOMY, P117