On phagocytes and macular degeneration

被引：138

作者：

Guillonneau, Xavier ^{[1
]}

Eandi, Chiara M. ^{[2
]}

Paques, Michel ^{[1
,3
]}

Sahel, Jose-Alain ^{[1
,3
]}

Sapieha, Przemyslaw ^{[4
]}

Sennlaub, Florian ^{[1
]}

机构：

[1] UPMC Univ Paris 06, Sorbonne Univ, CNRS, INSERM,Inst Vis, 17 Rue Moreau, F-75012 Paris, France

[2] Univ Turin, Dept Surg Sci, Eye Clin, Turin, Italy

[3] Ctr Hosp Natl Ophtalmol QuinzeVingts, INSERM, DHOS CIC 503, Paris, France

[4] Univ Montreal, Maisonneuve Rosemont Hosp, Dept Ophthalmol, Res Ctr, Quebec City, PQ, Canada

来源：

PROGRESS IN RETINAL AND EYE RESEARCH | 2017年 / 61卷

基金：

欧洲研究理事会;

关键词：

COMPLEMENT FACTOR-H; MONOCYTE CHEMOATTRACTANT PROTEIN-1; RETINAL-PIGMENT EPITHELIUM; AGE-RELATED MACULOPATHY; CCL2/CX3CR1 CHEMOKINE DEFICIENCIES; CHOROIDAL NEOVASCULAR MEMBRANE; REVERSE CHOLESTEROL TRANSPORT; SUBRETINAL DRUSENOID DEPOSITS; APOLIPOPROTEIN-E POLYMORPHISM; MEDIATED DARK-ADAPTATION;

D O I：

10.1016/j.preteyeres.2017.06.002

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Age related macular degeneration (AMD) is a complex multifactorial disease caused by the interplay of age and genetic and environmental risk factors. A common feature observed in early and both forms of late AMD is the breakdown of the physiologically immunosuppressive subretinal environment and the protracted accumulation of mononuclear phagocytes (MP). We here discuss the origin and nature of subretinal MPs, the mechanisms that lead to their accumulation, the inflammatory mediators they produce as well as the consequences of their chronic presence on photoreceptors, retinal pigment epithelium and choroid. Recent advances highlight how both genetic and environmental risk factors directly promote subretinal inflammation and tip the balance from a beneficial inflammation that helps control debris accumulation to detrimental chronic inflammation and destructive late AMD. Finally, we discuss how changes in life style or pharmacological intervention can help to break the vicious cycle of inflammation and degeneration, restore the immunosuppressive properties of the subretinal space, and reestablish homeostasis. (c) 2017 Elsevier Ltd. All rights reserved.

引用

收藏

页码：98 / 128

页数：31

相关论文

共 392 条

[31] Thrombospondins function as regulators of angiogenesis [J].

Bornstein, Paul .

JOURNAL OF CELL COMMUNICATION AND SIGNALING, 2009, 3 (3-4) :189-200

[32] Constitutive retinal CD200 expression regulates resident microglia and activation state of inflammatory cells during experimental autoimmune uveoretinitis [J].

Broderick, C ;

Hoek, RM ;

Forrester, JV ;

Liversidge, J ;

Sedgwick, JD ;

Dick, AD .

AMERICAN JOURNAL OF PATHOLOGY, 2002, 161 (05) :1669-1677

[33] CCR2/CCL2-mediated inflammation protects photoreceptor cells from amyloid-β-induced apoptosis [J].

Bruban, Julien ;

Maoui, Agathe ;

Chalour, Naima ;

An, Na ;

Jonet, Laurent ;

Feumi, Charles ;

Treton, Jacques ;

Sennlaub, Florian ;

Behar-Cohen, Francine ;

Mascarelli, Frederic ;

Dinet, Virginie .

NEUROBIOLOGY OF DISEASE, 2011, 42 (01) :55-72

[34] CRB1 Mutations in Inherited Retinal Dystrophies [J].

Bujakowska, Kinga ;

Audo, Isabelle ;

Mohand-Said, Saddek ;

Lancelot, Marie-Elise ;

Antonio, Aline ;

Germain, Aurore ;

Leveillard, Thierry ;

Letexier, Melanie ;

Saraiva, Jean-Paul ;

Lonjou, Christine ;

Carpentier, Wassila ;

Sahel, Jose-Alain ;

Bhattacharya, Shomi S. ;

Zeitz, Christina .

HUMAN MUTATION, 2012, 33 (02) :306-315

[35] Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE ε4/ε4 genotype accelerates HIV disease progression [J].

Burt, Trevor D. ;

Agan, Brian K. ;

Marconi, Vincent C. ;

He, Weijing ;

Kulkarni, Hemant ;

Mold, Jeffrey E. ;

Cavrois, Marielle ;

Huang, Yadong ;

Mahley, Robert W. ;

Dolan, Matthew J. ;

McCune, Joseph M. ;

Ahuja, Sunil K. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (25) :8718-8723

[36] Effects of gut microbiota on obesity and atherosclerosis via modulation of inflammation and lipid metabolism [J].

Caesar, R. ;

Fak, F. ;

Backhed, F. .

JOURNAL OF INTERNAL MEDICINE, 2010, 268 (04) :320-328

[37] Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling [J].

Caesar, Robert ;

Tremaroli, Valentina ;

Kovatcheva-Datchary, Petia ;

Cani, Patrice D. ;

Backhed, Fredrik .

CELL METABOLISM, 2015, 22 (04) :658-668

[38] Blood-derived macrophages infiltrate the retina and activate Muller glial cells under experimental choroidal neovascularization [J].

Caicedo, A ;

Espinosa-Heidmann, DG ;

Piña, Y ;

Hernandez, EP ;

Cousins, SW .

EXPERIMENTAL EYE RESEARCH, 2005, 81 (01) :38-47

[39] Complement Factor H Inhibits CD47-Mediated Resolution of Inflammation [J].

Calippe, Bertrand ;

Augustin, Sebastien ;

Beguier, Fanny ;

Charles-Messance, Hugo ;

Poupel, Lucie ;

Conart, Jean-Baptiste ;

Hu, Shulong J. ;

Lavalette, Sophie ;

Fauvet, Alexandre ;

Rayes, Julie ;

Levy, Olivier ;

Raoul, William ;

Fitting, Catherine ;

Denefle, Thomas ;

Pickering, Matthew C. ;

Harris, Claire ;

Jorieux, Sylvie ;

Sullivan, Patrick M. ;

Sahel, Jose -Alain ;

Karoyan, Philippe ;

Sapieha, Przemyslaw ;

Guillonneau, Xavier ;

Gautier, Emmanuel L. ;

Sennlaub, Florian .

IMMUNITY, 2017, 46 (02) :261-272

[40] Association of Choroidal Interleukin-17-Producing T Lymphocytes and Macrophages with Geographic Atrophy [J].

Camelo, Serge ;

Lavelette, Sophie ;

Guillonneau, Xavier ;

Raoul, William ;

Sennlaub, Florian .

OPHTHALMOLOGICA, 2016, 236 (01) :53-58

← 1 2 3 4 5 6 7 8 9 10 →