Impact of 18F-FDG PET/CT in Staging Patients With Small Cell Lung Cancer: A Systematic Review and Meta-Analysis

被引：36
作者：
Martucci, Francesco [1 ]
Pascale, Mariarosa [2 ]
Valli, Maria Carla [1 ]
Pesce, Gianfranco A. [1 ]
Froesch, Patrizia [3 ]
Giovanella, Luca [4 ]
Richetti, Antonella [1 ]
Treglia, Giorgio [4 ,5 ,6 ,7 ]
机构：
[1] Ente Osped Cantonale, Clin Radiat Oncol, Oncol Inst Southern Switzerland, Bellinzona, Switzerland
[2] Ente Osped Cantonale, Clin Trial Unit, Bellinzona, Switzerland
[3] Ente Osped Cantonale, Oncol Inst Southern Switzerland, Clin Med Oncol, Bellinzona, Switzerland
[4] Ente Osped Cantonale, Imaging Inst Southern Switzerland, Clin Nucl Med, Bellinzona, Switzerland
[5] Lausanne Univ Hosp, Dept Nucl Med & Mol Imaging, Lausanne, Switzerland
[6] Univ Lausanne, Lausanne, Switzerland
[7] Ente Osped Cantonale, Hlth Technol Assessment Unit, Acad Educ Res & Innovat Area, Gen Directorate, Bellinzona, Switzerland
来源：
FRONTIERS IN MEDICINE | 2020年 / 6卷
关键词：
positron emission tomography; CT; molecular imaging; staging; lung cancer; small cell lung cancer; POSITRON-EMISSION-TOMOGRAPHY; MANAGEMENT; SURVIVAL; DISEASE; SCAN; SCLC; TOOL; CT;
D O I：
10.3389/fmed.2019.00336
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: Molecular imaging methods are currently used in the management of patients with lung cancer. Compared to non-small cell lung cancer, less data are available about the impact of molecular imaging using fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (F-18-FDG PET/CT) in staging patients with small cell lung cancer (SCLC). Performing a systematic review and meta-analysis, we aimed to provide quantitative data about the impact of F-18-FDG PET/CT in staging SCLC. Methods: A comprehensive literature search of studies on the use of F-18-FDG PET/CT in patients with SCLC was performed. Three different databases were screened (PubMed/MEDLINE, EMBASE, and Cochrane library databases) until June 2019. Only articles describing the impact of F-18-FDG PET/CT in staging patients with SCLC were selected. A pooled analysis evaluating the change of binary SCLC staging (limited-stage vs. extensive-stage disease) using F-18-FDG PET/CT was carried out. Results: Nine articles including 721 patients with SCLC were included in the systematic review. Compared to conventional staging, a superior diagnostic accuracy of F-18-FDG PET/CT was found. A change of binary SCLC staging using F-18-FDG PET/CT was demonstrated in 15% (95% confidence interval, 9-21%) of patients with SCLC. Currently, it is not clearly demonstrated that the use of F-18-FDG PET/CT for staging may improve the survival outcome of patients with SCLC. Conclusions: F-18-FDG PET/CT is a useful molecular imaging method for staging patients with SCLC because it can change the management in a significant number of patients. More large prospective studies and cost-effectiveness analyses on the impact of F-18-FDG PET/CT in staging patients with SCLC are needed.
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