Comparative bone tissue integration of nanostructured and microroughened dental implants

被引：3

作者：

Salou, Laetitia ^{[1
,2
,3
]}

Hoornaert, Alain ^{[4
]}

Stanovici, Julien ^{[1
]}

Briand, Sylvain ^{[1
,5
]}

Louarn, Guy ^{[3
]}

Layrolle, Pierre ^{[1
]}

机构：

[1] Univ Nantes, INSERM, U957, Lab Pathophysiol Bone Resorpt,Fac Med, F-44035 Nantes, France

[2] Biomed Tissues, Nantes, France

[3] CNRS, Inst Mat, Nantes, France

[4] CHU Nantes, Fac Dent Surg, F-44035 Nantes 01, France

[5] Univ Hosp Nantes, CHU Nantes, Dept Orthopaed Surg, Nantes, France

来源：

NANOMEDICINE | 2015年 / 10卷 / 05期

关键词：

bone-to-implant contact; dental implant; nanostructure; osseointegration; titanium; TIO2; NANOTUBES; CELL-DIFFERENTIATION; SURFACE-ROUGHNESS; TITANIUM IMPLANTS; OSSEOINTEGRATION; FABRICATION; EXPRESSION; ADHESION; DIAMETER;

D O I：

10.2217/NNM.14.223

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim: The aim was to compare osteointegration of nanostructured implants to a microsurface widely used for titanium dental implants. Materials & methods: Commercial titanium dental implants with smooth or microroughened surfaces were nanostructured. Implants were inserted into the femoral condyles of rabbits. After 2 and 4 weeks, histomorphometry calculation was performed. Results: Nanotubes measuring 60 nm in diameter were observed on both S-NANO (roughness: 0.05 mu m) and R-NANO (roughness: 0.40 mu m) surfaces. The MICRO surface exhibited typical random cavities (roughness: 2.09 mu m). At 4 weeks, bone-to-implant contact values were significantly higher for the R-NANO than for the MICRO surface while no differences were observed at 2 weeks. Conclusion: Overall, this study shows that the nanostructured surfaces improved osteointegration similar or higher than the MICRO.

引用

页码：741 / 751

页数：11