Histological Evidence of Traditional Serrated Adenoma Originating from a Goblet Cell Hyperplastic Polyp A Case Report

BACKGROUND: Serrated polyps of the colorectum are now considered to be a heterogeneous group of polyps. There is debate about the progression of these serrated polyps in a continuous spectrum. We report a case of traditional serrated adenoma (TSA) in the rectum arising from a goblet cell hyperplastic polyp (HP). CASE: A 44-year-old, Chinese man presented with abdominal discomfort of 3 months' duration. Colonoscopy revealed a pedunculated polyp about 10 mm in diameter in the rectum. The polyp was removed by conventional snare polypectomy. Histopathologic examination showed that TSA and goblet cell HP coexisted in the polyp. Follow-up colonoscopy revealed no recurrence 6 months after the polypectomy. CONCLUSION: This case provides histological evidence that TSA originates from a goblet cell HP, and also suggests that HPs should not be considered as nonneoplastic lesions without malignant potential.