Stiff-Person Syndrome: A Case Report and Review of the Literature

被引：7

作者：

Egwuonwu, Steve ^{[1
]}

Chedebeau, Fernando ^{[1
]}

机构：

[1] Texas Tech Univ, Hlth Sci Ctr, Paul L Foster Sch Med, Dept Internal Med, El Paso, TX 79905 USA

来源：

JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION | 2010年 / 102卷 / 12期

关键词：

stiff-person syndrome; anemia; diabetes mellitus; PROTEIN;

D O I：

10.1016/S0027-9684(15)30757-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a case of stiff-person syndrome associated with several autoimmune diseases. A 49-year-old male with type 1 diabetes presented with a 6-month history of muscle rigidity and spasms of his upper and lower extremities. Anti-glutamic acid decarboxylase 65 antibody was elevated at 609 nmol/L. Electromyography revealed continuous motor unit activity in agonist and antagonist muscles. He responded favorably to diazepam, baclofen, and intravenous immunoglobulin infusions. This case report describes stiff-person syndrome in association with pernicious anemia and diabetes mellitus. A review of the literature discusses the diagnosis and treatment of this rare entity.

引用

页码：1261 / 1263

页数：3

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