Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: A safe treatment option for intraperitoneal rhabdomyosarcoma in children below 5 years of age

被引：16

作者：

Gesche, Jens ^{[1
]}

Beckert, Stefan ^{[2
]}

Neunhoeffer, Felix ^{[3
]}

Kachanov, Denis ^{[4
]}

Koenigsrainer, Alfred ^{[2
]}

Seitz, Guido ^{[5
]}

Fuchs, Joerg ^{[1
]}

机构：

[1] Univ Childrens Hosp, Dept Pediat Surg, Tubingen, Germany

[2] Univ Tubingen, Comprehens Canc Ctr, Dept Gen Visceral & Transplant Surg, Tubingen, Germany

[3] Univ Childrens Hosp, Dept Pediat Cardiol Pulmol & Pediat Intens Care M, Tubingen, Germany

[4] Natl Res Ctr Pediat Hematol Oncol & Immunol, Dept Clin Oncol, Moscow, Russia

[5] Univ Hosp Giessen Marburg, Dept Pediat Surg, Marburg, Germany

来源：

PEDIATRIC BLOOD & CANCER | 2019年 / 66卷 / 02期

关键词：

childhood cancer; cytoreductive surgery; hyperthermic intraperitoneal chemotherapy; rhabdomyosarcoma; sarcomatosis; toxicity; SOFT-TISSUE SARCOMA; PERITONEAL CARCINOMATOSIS; ADOLESCENTS; EXPERIENCE; EFFICACY; HIPEC;

D O I：

10.1002/pbc.27517

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Advanced and relapsed intraperitoneal rhabdomyosarcomas in young children represent an oncological challenge and options for local tumor control are limited. Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is commonly used in advanced peritoneal tumors in adults. However, no studies are available regarding CRS and HIPEC in young children. We report our experiences treating six patients with intraperitoneal rhabdomyosarcoma with CRS and HIPEC using cisplatin and doxorubicin focusing on safety and outcomes. No procedure-associated mortalities occurred and no major short- or long-term toxicities were recorded. All patients showed no evidence of disease after 12-month median (7-41) follow-up.

引用

页数：5

共 20 条

[1] Hyperthermic intraperitoneal chemotherapy after cytoreductive surgery for the treatment of peritoneal carcinomatosis in pediatric solid malignancies: a single institution experience [J].

Bautista, Francisco ;

Elias, Dominique ;

Pasqualini, Claudia ;

Valteau-Couanet, Dominique ;

Brugieres, Laurence .

JOURNAL OF PEDIATRIC SURGERY, 2014, 49 (08) :1276-1279

[2] Does aggressive local treatment have an impact on survival in children with metastatic rhabdomyosarcoma? [J].

Ben Arush, M. ;

Minard-Colin, V. ;

Mosseri, V. ;

Defachelles, A. S. ;

Bergeron, C. ;

Algret, N. ;

Fasola, S. ;

Andre, N. ;

Thebaud, E. ;

Corradini, N. ;

Bernier, V. ;

Martelli, H. ;

Ranchere, D. ;

Orbach, D. .

EUROPEAN JOURNAL OF CANCER, 2015, 51 (02) :193-201

[3] Cooperative Trial CWS-91 for Localized Soft Tissue Sarcoma in Children, Adolescents, and Young Adults [J].

Dantonello, Tobias M. ;

Int-Veen, Christoph ;

Harms, Dieter ;

Leuschner, Ivo ;

Schmidt, Bernhard F. ;

Herbst, Manfred ;

Juergens, Heribert ;

Scheel-Walter, Hans-Gerhard ;

Bielack, Stefan S. ;

Klingebiel, Thomas ;

Dickerhoff, Roswitha ;

Kirsch, Sylvia ;

Brecht, Ines ;

Schmelzle, Rainer ;

Greulich, Michael ;

Gadner, Helmut ;

Greiner, Jeanette ;

Marky, Ildiko ;

Treuner, Joern ;

Koscielniak, Ewa .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (09) :1446-1455

[4] Rhabdomyosarcoma [J].

Dasgupta, Roshni ;

Fuchs, Joerg ;

Rodeberg, David .

SEMINARS IN PEDIATRIC SURGERY, 2016, 25 (05) :276-283

[5] Radiation therapy target volume reduction in pediatric rhabdomyosarcoma Implications for Patterns of Disease Recurrence and Overall Survival [J].

Eaton, Bree R. ;

McDonald, Mark W. ;

Kim, Sungjin ;

Marcus, Robert B., Jr. ;

Sutter, Anna L. ;

Chen, Zhengjia ;

Esiashvili, Natia .

CANCER, 2013, 119 (08) :1578-1585

[6] Chemotherapy for intraperitoneal use: a review of hyperthermic intraperitoneal chemotherapy and early post-operative intraperitoneal chemotherapy [J].

Goodman, Martin D. ;

McPartland, Sarah ;

Detelich, Danielle ;

Saif, Muhammad Wasif .

JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2016, 7 (01) :45-57

[7]

Green HLH., 2014, J PEDIAT ONCOL, V2, P10, DOI DOI 10.14205/2309-3021.2014.02.01.2

[8] Toxicity of hyperthermic intraperitoneal chemotherapy (HIPEC) in pediatric patients with sarcomatosis/carcinomatosis: Early experience and phase 1 results [J].

Hayes-Jordan, A. ;

Green, H. ;

Ludwig, J. ;

Anderson, P. .

PEDIATRIC BLOOD & CANCER, 2012, 59 (02) :395-397

[9] Cytoreductive Surgery Followed by Hyperthermic Intraperitoneal Chemotherapy in DSRCT: Progress and Pitfalls [J].

Hayes-Jordan, Andrea .

CURRENT ONCOLOGY REPORTS, 2015, 17 (08)

[10] Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Children, Adolescents, and Young Adults: The First 50 Cases [J].

Hayes-Jordan, Andrea ;

Green, Holly ;

Lin, Heather ;

Owusu-Agyemang, Pascal ;

Mejia, Rodrigo ;

Okhuysen-Cawley, Regina ;

Cortes, Jose ;

Fitzgerald, Nancy E. ;

McAleer, Mary Frances ;

Herzog, Cynthia ;

Huh, Winston W. ;

Anderson, Peter .

ANNALS OF SURGICAL ONCOLOGY, 2015, 22 (05) :1726-1732

← 1 2 →