Industry 4.0 is an innovation framework launched initially at the 2011 Hanover Fair in Germany. It is premised on extreme digital connectivity to build smart factories and deliver extreme automation in science and society. Industry 4.0 has recently scaled up worldwide beyond Germany and Europe. Industry 4.0 employs the Internet of Things (IoT) to connect, communicate, and collect big data from embedded sensors in living and inanimate objects. When we add artificial intelligence (AI) powered real-time data analyses to the IoT, a state of worldwide extreme connectivity, or The Quantified Planet, is created. By its focus on connectivity at a systems scale, the Industry 4.0 is of interest to health products manufacturing and service automation in medicine, biology, ecology, and society. But there are also unchecked assumptions. This article poses a question that has so far been neglected in the Industry 4.0 innovation echo chamber. Is it always good to have pervasive connectivity and extreme integration to the point that everything is connected to everything else? For example, extreme connectivity creates an All Your Eggs in One Basket problem and thus potential for complete network collapse in a domino effect when a component in a highly integrated system fails. Digital connectivity cultivates a fertile ground for new social and political power structures for authoritarian governance (i.e., a worrisome state of pansurveillance) by one person in total control of knowledge networks in science and society, directly or through connected proxies. Filter bubbles created by extreme digital connectivity and AI can result in compressed foresight, lackluster innovation, and monocultures in laboratory life. The way forward is to harness Industry 4.0 and connectivity without such digital network toxicity. Similar to fire exits in skyscrapers and other built environments, designing innovation systems with extreme connectivity demands that we also think of exit plans from the omnipresent digital networks, IoT, and The Quantified Planetboth for safety and sustained creativity. Finally, the relationship between new technologies and society is far from being a simple one-directional interaction; it is not the technologies that cause social disruption. On the contrary, it is the value-loaded decisions made by individuals, organizations, and other social actors that shape sociotechnical change. Recognizing the latter narrative is important because it informs how we do science and can best respond to uncertainties and opaque assumptions embedded in emerging technologies such as AI, IoT, and Industry 4.0.
