Male C57BL6/N and C57BL6/J Mice Respond Differently to Constant Light and Running-Wheel Access

被引:27
作者
Capri, Kimberly M. [1 ,2 ]
Maroni, Marissa J. [1 ,3 ]
Deane, Hannah, V [1 ]
Concepcion, Holly A. [1 ]
DeCourcey, Holly [1 ]
Logan, Ryan W. [4 ,5 ]
Seggio, Joseph A. [1 ]
机构
[1] Bridgewater State Univ, Dept Biol Sci, Bridgewater, MA 02324 USA
[2] Boston Univ, Dept Math & Stat, Boston, MA 02215 USA
[3] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA
[4] Univ Penn, Dept Psychiat, Translat Neurosci Program, Philadelphia, PA 19104 USA
[5] Jackson Lab, Ctr Syst Neurogenet Addict, 600 Main St, Bar Harbor, ME 04609 USA
关键词
mouse model; circadian rhythm; strain difference; mice; constant light; running wheel; ANXIETY-LIKE BEHAVIORS; VOLUNTARY EXERCISE; CIRCADIAN-RHYTHMS; PHASE-SHIFTS; STRESS; NIGHT; RATS; INSULIN; OBESITY; C57BL/6N;
D O I
10.3389/fnbeh.2019.00268
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Previous studies have shown that exposure to circadian disruption produces negative effects on overall health and behavior. More recent studies illustrate that strain differences in the behavioral and physiological responses to circadian disruption exist, even if the strains have similar genetic backgrounds. As such, we investigated the effects of constant room-level light (LL) with running-wheel access on the behavior and physiology of male C57BL6/J from Jackson Laboratories and C57BL6/N from Charles River Laboratories mice. Mice were exposed to either a 12:12 light-dark (LD) cycle or LL and given either a standard home cage or a cage with a running-wheel. Following 6 weeks of LD or LL, their response to behavioral assays (open-field, light-dark box, novel object) and measures of metabolism were observed. Under standard LD, C57BL6/J mice exhibited increased locomotor activity and reduced exploratory behavior compared to C57BL6/N mice. In LL, C57BL6/J mice had greater period lengthening and increased anxiety, while C57BL6/N mice exhibited increased weight gain and no change in exploratory behavior. C57BL6/J mice also decreased exploration with running-wheel access while C57BL6/N mice did not. These results further demonstrate that C57BL/6 substrains exhibit different behavioral and physiological responses to circadian disruption and wheel-running access.
引用
收藏
页数:9
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