Seizure-induced basal dendrites on granule cells

被引：0

作者：

Ribak, Charles E. ^{[1
]}

Shapiro, Lee A. ^{[2
]}

Yan, Xiao-Xin ^{[3
]}

Dashtipour, Khashayar ^{[4
]}

Nadler, J. Victor ^{[5
]}

Obenaus, Andre ^{[4
]}

Spigelman, Igor ^{[6
]}

Buckmaster, Paul S. ^{[7
]}

机构：

[1] Univ Calif Irvine, Irvine, CA 92623 USA

[2] Texas A&M Univ, College Stn, TX USA

[3] So Illinois Univ, Carbondale, IL 62901 USA

[4] Loma Linda Univ, Loma Linda, CA 92350 USA

[5] Duke Univ, Durham, NC USA

[6] Univ Calif Los Angeles, Los Angeles, CA USA

[7] Stanford Univ, Stanford, CA 94305 USA

来源：

EPILEPSIA | 2010年 / 51卷

关键词：

Astrocytes; Doublecortin; Electron microscopy; Epilepsy; Excitation; Neurogenesis; Neuroplasticity; TEMPORAL-LOBE EPILEPSY; RAT MODEL;

D O I：

10.1111/j.1528-1167.2010.02829.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Seizure-induced hilar basal dendrites on dentate granule cells are observed in several rodent models of temporal lobe epilepsy. Ultrastructural evidence showed that basal dendrites receive predominantly excitatory synapses, including many from mossy fibers. Such highly interconnected granule cells with basal dendrites are suggested to enhance hyperexcitability within the dentate network. For an expanded treatment of this topic see Jasper's Basic Mechanisms of the Epilepsies, Fourth Edition (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at). © 2010 International League Against Epilepsy.

引用

页码：43 / 43

页数：1

共 5 条

[1]

Ribak CE, 2000, J COMP NEUROL, V428, P240, DOI 10.1002/1096-9861(20001211)428:2<240::AID-CNE4>3.0.CO

[2]

2-Q

[3] Newly generated granule cells show rapid neuroplastic changes in the adult rat dentate gyrus during the first five days following pilocarpine-induced seizures [J].