Adherence and the pediatric transplant patient

Adherence is proving to be the Achilles heel of pediatric transplantation. Through a careful literature review on adherence in pediatric solid-organ transplantation from 2007 to 2017, this chapter reports on the incidence, measuring tools, and consequences of poor adherence. We detail adherence determinants and interventions proposed to foster it. While adherence is a major problem in the adolescent age, it clearly is not limited to this age group. Importantly, it is not one to start tackling at that time or when it becomes apparent. Rather, fostering adherence should be built throughout the continuum of the transplant journey, starting in the pretransplantation phase. Adherence is clearly a fluid state, necessitating frequent reassessments and enforcement. Adherence in addition shares similar determinants with quality of life. The severe consequences in the case of poor adherence mandate that the transplant community prioritize it as the next frontier in transplantation. Good adherence is what will pave the road to tolerance, cost-efficient transplantation, and optimized long-term outcomes. (C) 2017 Elsevier Inc. All rights reserved.