Rh-catalyzed asymmetric hydrogenation of γ-phthalimido-substituted α,β-unsaturated carboxylic acid esters:: An efficient enantioselective synthesis of β-aryl-γ-amino acids

被引：60
作者：
Deng, Jun
Duan, Zheng-Chao
Huang, Jia-Di
Hu, Xiang-Ping [1 ]
Wang, Dao-Yong
Yu, Sai-Bo
Xu, Xue-Feng
Zheng, Zhuo
机构：
[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
来源：
ORGANIC LETTERS | 2007年 / 9卷 / 23期
关键词：
D O I：
10.1021/ol702193v
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of chiral beta-aryl-gamma-amino acid ester derivatives were synthesized in high enantioselectivities (93-97% ee) via the Rh-catalyzed asymmetric hydrogenation of gamma-phthalimido-alpha,beta-unsaturated carboxylic acid esters using highly modular chiral BoPhoz-type phosphine-aminophosphine ligands. The method has been applied successfully to the synthesis of several chiral pharmaceuticals including (R)-baclofen and (R)-rolipram with high enantioselectivities.
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页码：4825 / 4828
页数：4
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