Synthesis and structure-activity relationships of novel 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide derivatives as potential agents against A549 lung cancer cells

被引：161
|
作者：
Xia, Yong
Dong, Zhi-Wu
Zhao, Bao-Xiang [1 ]
Ge, Xiao
Meng, Ning
Shin, Dong-Soo
Miao, Jun-Ying
机构：
[1] Shandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Peoples R China
[2] Shandong Univ, Sch Life Sci, Inst Dev Biol, Jinan 250100, Peoples R China
[3] Changwon Natl Univ, Dept Chem, Chang Won 641773, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2007年 / 15卷 / 22期
关键词：
pyrazole carbohydrazide; A549; cells; apoptosis; structure-activity relationship; OXIDE INDUCES APOPTOSIS; PRELIMINARY BIOLOGICAL EVALUATION; GROWTH-INHIBITORY-ACTIVITY; SURVIVAL FACTORS; SAFROLE; ANTICANCER; DISCOVERY; DESIGN; 1-ETHOXY-3-(3,4-METHYLENEDIOXYPHENYL)-2-PROPANOL; INTEGRIN-BETA-4;
D O I：
10.1016/j.bmc.2007.08.021
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of novel 1-arylmethyl-3-aryl- 1 H-pyrazole-5-carbohydrazide derivatives were synthesized, and the effects of all the compounds on A549 cell growth were investigated. The results showed that all the nine compounds had inhibitory effects on the growth of A549 cells and induced the cell apoptosis. The study on Structure-activity relationships and prediction of lipophilicities Of compounds showed that compounds with log P values in the range of 3.12-4.94 had more inhibitory effects oil the growth of A549 cells. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6893 / 6899
页数：7
相关论文
共 50 条
  • [1] Synthesis and structure-activity relationships of novel 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide hydrazone derivatives as potential agents against A549 lung cancer cells
    Xia, Yong
    Fan, Chuan-Dong
    Zhao, Bao-Xiang
    Zhao, Jing
    Shin, Dong-Soo
    Miao, Jun-Ying
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2008, 43 (11) : 2347 - 2353
  • [2] Synthesis and discovery of autophagy inducers for A549 and H460 lung cancer cells, novel 1-(2′-hydroxy-3′-aroxypropyl)-3-aryl-1H-pyrazole-5-carbohydrazide derivatives
    Fan, Chuan-Dong
    Zhao, Bao-Xiang
    Wei, Fang
    Zhang, Gai-Hua
    Dong, Wen-Liang
    Miao, Jun-Ying
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (14) : 3860 - 3864
  • [3] Synthesis of novel substituted pyrazole-5-carbohydrazide hydrazone derivatives and discovery of a potent apoptosis inducer in A549 lung cancer cells
    Zheng, Liang-Wen
    Wu, Ling-Ling
    Zhao, Bao-Xiang
    Dong, Wen-Liang
    Miao, Jun-Ying
    BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 17 (05) : 1957 - 1962
  • [4] Structure-activity relationships and the cytotoxic effects of novel diterpenoid alkaloid derivatives against A549 human lung carcinoma cells
    Wada, Koji
    Hazawa, Masaharu
    Takahashi, Kenji
    Mori, Takao
    Kawahara, Norio
    Kashiwakura, Ikuo
    JOURNAL OF NATURAL MEDICINES, 2011, 65 (01) : 43 - 49
  • [5] Synthesis and bioactivity evaluation of ethyl 1-arylmethyl-3-aryl-1-H-pyrazole-5-carboxylate derivatives
    Ding, Xiao-Ling
    Meng, Ning
    Xia, Yong
    Wang, Li-Juan
    Zhang, Xiao-Feng
    Zhao, Bao-Xiang
    Miao, Jun-Ying
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2007, 27 (12) : 1542 - 1546
  • [6] Synthesis and preliminary biological evaluation of novel pyrazolo[1,5-a] pyrazin-4(5H)-one derivatives as potential agents against A549 lung cancer cells
    Zhang, Jin-Hua
    Fan, Chuan-Dong
    Zhao, Bao-Xiang
    Shin, Dong-Soo
    Dong, Wen-Liang
    Xie, Yong-Sheng
    Miao, Jun-Ying
    BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (24) : 10165 - 10171
  • [7] Synthesis and cytotoxic activity of novel 3-(1H-indol-3-yl)-1H-pyrazole-5-carbohydrazide derivatives
    Zhang, Datong
    Wang, Guangtian
    Zhao, Guilong
    Xu, Weiren
    Huo, Lingyan
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 46 (12) : 5868 - 5877
  • [8] Structure–activity relationships and the cytotoxic effects of novel diterpenoid alkaloid derivatives against A549 human lung carcinoma cells
    Koji Wada
    Masaharu Hazawa
    Kenji Takahashi
    Takao Mori
    Norio Kawahara
    Ikuo Kashiwakura
    Journal of Natural Medicines, 2011, 65 : 43 - 49
  • [9] Synthesis of Novel Pyrazole Derivatives Containing lsatins as Potential Apoptosis Inducer in Non-small Lung Cancer A549 Cells
    Zhang, Lei
    Li, Wenyun
    Liu, Lai
    Zheng, Chengyue
    Wang, Yang
    Xu, Yingshu
    Shi, Dabin
    Nie, Xuqiang
    Guo, Jiaying
    Zhu, Chunyuan
    Wang, Jing
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2017, 37 (07) : 1721 - 1729
  • [10] Synthesis of novel ribavirin hydrazone derivatives and anti-proliferative activity against A549 lung cancer cells
    Liu, Wei-Yong
    Li, Hai-Ying
    Zhao, Bao-Xiang
    Shin, Dong-Soo
    Lian, Song
    Miao, Jun-Ying
    CARBOHYDRATE RESEARCH, 2009, 344 (11) : 1270 - 1275
12345