A new model for the origin of kinetic hydrogen isotope effects

被引：42

作者：

Klinman, Judith P. ^{[1
,2
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

来源：

JOURNAL OF PHYSICAL ORGANIC CHEMISTRY | 2010年 / 23卷 / 07期

关键词：

C-H activation; enzymes; heavy atom motions; isotope effects; tunneling; TRANSITION-STATE THEORY; TEMPERATURE-DEPENDENCE; HYDRIDE-TRANSFER; SOYBEAN LIPOXYGENASE-1; THEORETICAL-ANALYSIS; ENZYME-KINETICS; PROTON; MECHANISM; DYNAMICS; REACTIVITY;

D O I：

10.1002/poc.1661

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Measurements of kinetic hydrogen isotope effects in enzymatic C-H bond cleavage reactions have generated a body of data that is inconsistent with either a semi-classical formalism for the origin of the isotope effects or a semi-classical formalism together with a modest degree of hydrogen tunneling. A model that treats the movement of hydrogen as a wave, and whose behavior is dictated by the heavy atom environment, is presented and discussed. A list of unanswered questions and challenges is given at the end of this paper. Copyright (C) 2010 John Wiley & Sons, Ltd.

引用

页码：606 / 612

页数：7

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