Multiple sclerosis-associated fatigue

被引：96
作者：
Krupp, Lauren B. [1 ]
Serafin, Dana J. [1 ]
Christodoulou, Christopher [1 ]
机构：
[1] SUNY Stony Brook, Dept Neurol, Med Ctr, Stony Brook, NY 11794 USA
来源：
EXPERT REVIEW OF NEUROTHERAPEUTICS | 2010年 / 10卷 / 09期
关键词：
fatigue; multiple sclerosis; quality of life; rating scales; sleep; treatment; QUALITY-OF-LIFE; COGNITIVE-BEHAVIOR THERAPY; CORTICAL ACTIVATION; SEVERITY SCALE; FRONTAL-CORTEX; BRAIN ATROPHY; DOUBLE-BLIND; SELF-REPORT; DEPRESSION; SLEEP;
D O I：
10.1586/ERN.10.99
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Fatigue is an extremely prevalent issue for multiple sclerosis (MS) patients. Fatigue can affect quality of life, depression, anxiety, motor function and sleep patterns. There are a number of available rating scales designed to detect and assess fatigue. However, the pathophysiology of fatigue is still not completely understood and the treatment of this symptom remains difficult. A number of clinical trials for fatigue in MS have shown some benefit with different interventions, including medication, physical activity and cognitive behavioral therapy. Nonetheless, further research and the development of more targeted therapies are needed to improve the management of fatigue.
引用
收藏
页码：1437 / 1447
页数：11
相关论文
共 150 条
[1]  
Amarenco G, 1995, REV NEUROL, V151, P722
[2]   Quality of life in multiple sclerosis: the impact of depression, fatigue and disability [J].
Amato, MP ;
Ponziani, G ;
Rossi, F ;
Liedl, CL ;
Stefanile, C ;
Rossi, L .
MULTIPLE SCLEROSIS JOURNAL, 2001, 7 (05) :340-344
[3]  
[Anonymous], 2009, Guidance for industry: Patient-Reported outcome measures: Use in medical product development to support labeling claims
[4]   Quality of life among persons with multiple sclerosis and their caregivers [J].
Aronson, KJ .
NEUROLOGY, 1997, 48 (01) :74-80
[5]   The relationship of sleep disturbances and fatigue in multiple sclerosis [J].
Attarian, HP ;
Brown, KM ;
Duntley, SP ;
Carter, JD ;
Cross, AH .
ARCHIVES OF NEUROLOGY, 2004, 61 (04) :525-528
[6]   The relationship between subjective fatigue and cognitive fatigue in advanced multiple sclerosis [J].
Bailey, A. ;
Channon, S. ;
Beaumont, J. G. .
MULTIPLE SCLEROSIS JOURNAL, 2007, 13 (01) :73-80
[7]  
Bakshi R, 2000, MULT SCLER J, V6, P181, DOI 10.1191/135245800701566052
[8]   Fatigue in multiple sclerosis: Cross-sectional correlation with brain MRI findings in 71 patients [J].
Bakshi, R ;
Miletich, RS ;
Henschel, K ;
Shaikh, ZA ;
Janardhan, V ;
Wasay, M ;
Stengel, LM ;
Ekes, R ;
Kinkel, PR .
NEUROLOGY, 1999, 53 (05) :1151-1153
[9]   Changes in neuropsychological test performance over the workday in multiple sclerosis [J].
Beatty, WW ;
Goretti, B ;
Siracusa, G ;
Zipoli, V ;
Portaccio, E ;
Amato, MP .
CLINICAL NEUROPSYCHOLOGIST, 2003, 17 (04) :551-560
[10]   The psychology of fatigue in patients with multiple sclerosis: A review [J].
Bol, Yvonne ;
Duits, Annelien A. ;
Hupperts, Raymond M. M. ;
Vlaeyen, Johan W. S. ;
Verhey, Frans R. J. .
JOURNAL OF PSYCHOSOMATIC RESEARCH, 2009, 66 (01) :3-11
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