The Potential Value of the PI3K/Akt/mTOR Signaling Pathway for Assessing Prognosis in Cervical Cancer and as a Target for Therapy

被引：147

作者：

Bahrami, Afsane ^{[1
,2
]}

Hasanzadeh, Malihe ^{[3
]}

Hassanian, Seyed Mahdi ^{[4
,5
]}

ShahidSales, Soodabeh ^{[6
]}

Ghayour-Mobarhan, Majid ^{[4
]}

Ferns, Gordon A. ^{[7
]}

Avan, Amir ^{[4
,6
]}

机构：

[1] Mashhad Univ Med Sci, Dept Modern Sci & Technol, Fac Med, Mashhad, Iran

[2] Mashhad Univ Med Sci, Student Res Comm, Fac Med, Mashhad, Iran

[3] Mashhad Univ Med Sci, Dept Med Biochem, Fac Med, Mashhad, Iran

[4] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Iran

[5] Mashhad Univ Med Sci, Dept Gynecol Oncol, Woman Hlth Res Ctr, Fac Med, Mashhad, Iran

[6] Mashhad Univ Med Sci, Canc Res Ctr, Mashhad, Iran

[7] Brighton & Sussex Med Sch, Div Med Educ, Brighton BN1 9PH, E Sussex, England

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2017年 / 118卷 / 12期

关键词：

PI3K/Akt/mTOR SIGNALING PATHWAY; HUMAN PAPILLOMAVIRUSE; CERVICAL CANCER; ACTIVATED MAMMALIAN TARGET; INHIBITS PROLIFERATION; MOLECULAR TARGET; GENE-EXPRESSION; CARCINOMA CELLS; UNITED-STATES; PHASE-I; MTOR; AKT; E6;

D O I：

10.1002/jcb.26118

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cervical cancer is a common gynecological cancer and a leading cause of cancer-related death in women globally. There is a need for the identification of prognostic and predictive biomarker for risk stratification. The phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway is often dysregulated in cervical cancer, indicating that it may be a potential therapeutic target in the treatment of this malignancy, and could perhaps be used as a novel biomarker in the assessment of risk of developing cervical cancer. We aimed to provide an overview of the potential applications of the PI3K/Akt/mTOR pathway as biomarker for risk stratification, in predicting the prognosis of cervical cancer, and for developing new therapeutic approaches in patients with cervical cancer. J. Cell. Biochem. 118: 4163-4169, 2017. (c) 2017 Wiley Periodicals, Inc.

引用

页码：4163 / 4169

页数：7

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