Global Pharmacogenomics Within Precision Medicine: Challenges and Opportunities

被引：41

作者：

Chenoweth, Meghan J. ^{[1
,2
]}

Giacomini, Kathleen M. ^{[3
]}

Pirmohamed, Munir ^{[4
]}

Hill, Susan L. ^{[5
]}

van Schaik, Ron H. N. ^{[6
]}

Schwab, Matthias ^{[7
,8
]}

Shuldiner, Alan R. ^{[9
,10
,11
]}

Relling, Mary V. ^{[12
]}

Tyndale, Rachel F. ^{[1
,2
,13
]}

机构：

[1] Ctr Addict & Mental Hlth, Campbell Family Mental Hlth Res Inst, Toronto, ON, Canada

[2] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada

[3] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94143 USA

[4] Univ Liverpool, Inst Translat Med, Dept Mol & Clin Pharmacol, Liverpool, Merseyside, England

[5] NHS, London, England

[6] Erasmus MC, Dept Clin Chem, Rotterdam, Netherlands

[7] Univ Tubingen, Dept Clin Pharmacol & Biochem & Pharm, Tubingen, Germany

[8] Univ Tubingen, iFIT Cluster Excellence, Tubingen, Germany

[9] Regeneron Pharmaceut Inc, Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA

[10] Univ Maryland, Sch Med, Program Personalized & Genom Med, Baltimore, MD 21201 USA

[11] Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA

[12] St Jude Childrens Res Hosp, Pharmaceut Sci Dept, 332 N Lauderdale St, Memphis, TN 38105 USA

[13] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2020年 / 107卷 / 01期

基金：

欧盟地平线“2020”; 英国医学研究理事会; 美国国家卫生研究院; 加拿大健康研究院;

关键词：

D O I：

10.1002/cpt.1664

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This commentary focuses on challenges to the widespread adoption of pharmacogenomics, outlining issues that need to be addressed ranging from basic pharmacogenomics research through to implementation. Goals addressing each challenge are also presented, which aim to increase understanding, assessment, interpretation, accessibility, and adoption of pharmacogenomics in routine clinical practice.

引用

页码：57 / 61

页数：5

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