Global Pharmacogenomics Within Precision Medicine: Challenges and Opportunities

被引：39
作者：
Chenoweth, Meghan J. [1 ,2 ]
Giacomini, Kathleen M. [3 ]
Pirmohamed, Munir [4 ]
Hill, Susan L. [5 ]
van Schaik, Ron H. N. [6 ]
Schwab, Matthias [7 ,8 ]
Shuldiner, Alan R. [9 ,10 ,11 ]
Relling, Mary V. [12 ]
Tyndale, Rachel F. [1 ,2 ,13 ]
机构：
[1] Ctr Addict & Mental Hlth, Campbell Family Mental Hlth Res Inst, Toronto, ON, Canada
[2] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada
[3] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94143 USA
[4] Univ Liverpool, Inst Translat Med, Dept Mol & Clin Pharmacol, Liverpool, Merseyside, England
[5] NHS, London, England
[6] Erasmus MC, Dept Clin Chem, Rotterdam, Netherlands
[7] Univ Tubingen, Dept Clin Pharmacol & Biochem & Pharm, Tubingen, Germany
[8] Univ Tubingen, iFIT Cluster Excellence, Tubingen, Germany
[9] Regeneron Pharmaceut Inc, Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
[10] Univ Maryland, Sch Med, Program Personalized & Genom Med, Baltimore, MD 21201 USA
[11] Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA
[12] St Jude Childrens Res Hosp, Pharmaceut Sci Dept, 332 N Lauderdale St, Memphis, TN 38105 USA
[13] Univ Toronto, Dept Psychiat, Toronto, ON, Canada
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS | 2020年 / 107卷 / 01期
基金：
美国国家卫生研究院; 欧盟地平线“2020”; 英国医学研究理事会; 加拿大健康研究院;
关键词：
D O I：
10.1002/cpt.1664
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
This commentary focuses on challenges to the widespread adoption of pharmacogenomics, outlining issues that need to be addressed ranging from basic pharmacogenomics research through to implementation. Goals addressing each challenge are also presented, which aim to increase understanding, assessment, interpretation, accessibility, and adoption of pharmacogenomics in routine clinical practice.
引用
收藏
页码：57 / 61
页数：5
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  • [1] Genome-wide analysis of clopidogrel active metabolite levels identifies novel variants that influence antiplatelet response
    Backman, Joshua D.
    O'Connell, Jeffrey R.
    Tanner, Keith
    Peer, Cody J.
    Figg, William D.
    Spencer, Shawn D.
    Mitchell, Braxton D.
    Shuldiner, Alan R.
    Yerges-Armstrong, Laura M.
    Horenstein, Richard B.
    Lewis, Joshua P.
    [J]. PHARMACOGENETICS AND GENOMICS, 2017, 27 (04) : 159 - 163
  • [2] Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points-Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC)
    Bergmeijer, Thomas O.
    Reny, Jean-Luc
    Pakyz, Ruth E.
    Gong, Li
    Lewis, Joshua P.
    Kim, Eun-Young
    Aradi, Daniel
    Fernandez-Cadenas, Israel
    Horenstein, Richard B.
    Lee, Ming Ta Michael
    Whaley, Ryan M.
    Montaner, Joan
    Franco Gensini, Gian
    Cleator, John H.
    Chang, Kiyuk
    Holmvang, Lene
    Hochholzer, Willibald
    Roden, Dan M.
    Winter, Stefan
    Altman, Russ B.
    Alexopoulos, Dimitrios
    Kim, Ho-Sook
    Dery, Jean-Pierre
    Gawaz, Meinrad
    Bliden, Kevin
    Valgimigli, Marco
    Marcucci, Rossella
    Campo, Gianluca
    Schaeffeler, Elke
    Dridi, Nadia P.
    Wen, Ming-Shien
    Shin, Jae Gook
    Simon, Tabassome
    Fontana, Pierre
    Giusti, Betti
    Geisler, Tobias
    Kubo, Michiaki
    Trenk, Dietmar
    Siller-Matula, Jolanta M.
    ten Berg, Jurrien M.
    Gurbel, Paul A.
    Hulot, Jean-Sebastien
    Mitchell, Braxton D.
    Schwab, Matthias
    Ritchie, Marylyn DeRiggi
    Klein, Teri E.
    Shuldiner, Alan R.
    [J]. AMERICAN HEART JOURNAL, 2018, 198 : 152 - 159
  • [3] Genetic Variation Among 82 Pharmacogenes: The PGRNseq Data From the eMERGE Network
    Bush, W. S.
    Crosslin, D. R.
    Owusu-Obeng, A.
    Wallace, J.
    Almoguera, B.
    Basford, M. A.
    Bielinski, S. J.
    Carrell, D. S.
    Connolly, J. J.
    Crawford, D.
    Doheny, K. F.
    Gallego, C. J.
    Gordon, A. S.
    Keating, B.
    Kirby, J.
    Kitchner, T.
    Manzi, S.
    Mejia, A. R.
    Pan, V.
    Perry, C. L.
    Peterson, J. F.
    Prows, C. A.
    Ralston, J.
    Scott, S. A.
    Scrol, A.
    Smith, M.
    Stallings, S. C.
    Veldhuizen, T.
    Wolf, W.
    Volpi, S.
    Wiley, K.
    Li, R.
    Manolio, T.
    Bottinger, E.
    Brilliant, M. H.
    Carey, D.
    Chisholm, R. L.
    Chute, C. G.
    Haines, J. L.
    Hakonarson, H.
    Harley, J. B.
    Holm, I. A.
    Kullo, I. J.
    Jarvik, G. P.
    Larson, E. B.
    McCarty, C. A.
    Williams, M. S.
    Denny, J. C.
    Rasmussen-Torvik, L. J.
    Roden, D. M.
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2016, 100 (02) : 160 - 169
  • [4] Clinical Probes and Endogenous Biomarkers as Substrates for Transporter Drug-Drug Interaction Evaluation: Perspectives From the International Transporter Consortium
    Chu, Xiaoyan
    Liao, Mingxiang
    Shen, Hong
    Yoshida, Kenta
    Zur, Arik A.
    Arya, Vikram
    Galetin, Aleksandra
    Giacomini, Kathleen M.
    Hanna, Imad
    Kusuhara, Hiroyuki
    Lai, Yurong
    Rodrigues, David
    Sugiyama, Yuichi
    Zamek-Gliszczynski, Maciej J.
    Zhang, Lei
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2018, 104 (05) : 836 - 864
  • [5] The Detection of Androgen Receptor Splice Variant 7 in Plasma-derived Exosomal RNA Strongly Predicts Resistance to Hormonal Therapy in Metastatic Prostate Cancer Patients
    Del Re, Marzia
    Biasco, Elisa
    Crucitta, Stefania
    Derosa, Lisa
    Rofi, Eleonora
    Orlandini, Cinzia
    Miccoli, Mario
    Galli, Luca
    Falcone, Alfredo
    Jenster, Guido W.
    van Schaik, Ron H.
    Danesi, Romano
    [J]. EUROPEAN UROLOGY, 2017, 71 (04) : 680 - 687
  • [6] DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis
    Henricks, Linda M.
    Lunenburg, Carin A. T. C.
    de Man, Femke M.
    Meulendijks, Didier
    Frederix, Geert W. J.
    Kienhuis, Emma
    Creemers, Geert-Jan
    Baars, Arnold
    Dezentje, Vincent O.
    Imholz, Alexander L. T.
    Jeurissen, Frank J. F.
    Portielje, Johanna E. A.
    Jansen, Rob L. H.
    Hamberg, Paul
    ten Tije, Albert J.
    Droogendijk, Helga J.
    Koopman, Miriam
    Nieboer, Peter
    van de Poel, Marlene H. W.
    Mandigers, Caroline M. P. W.
    Rosing, Hilde
    Beijnen, Jos H.
    van Werkhoven, Erik
    van Kuilenburg, Andre B. P.
    van Schaik, Ron H. N.
    Mathijssen, Ron H. J.
    Swen, Jesse J.
    Gelderblom, Hans
    Cats, Annemieke
    Guchelaar, Henk-Jan
    Schellens, Jan H. M.
    [J]. LANCET ONCOLOGY, 2018, 19 (11) : 1459 - 1467
  • [7] Implementation of genotype-guided dosing of warfarin with point-of-care genetic testing in three UK clinics: a matched cohort study
    Jorgensen, Andrea L.
    Prince, Clare
    Fitzgerald, Gail
    Hanson, Anita
    Downing, Jennifer
    Reynolds, Julia
    Zhang, J. Eunice
    Alfirevic, Ana
    Pirmohamed, Munir
    [J]. BMC MEDICINE, 2019, 17 (1)
  • [8] Educational Innovations in Clinical Pharmacogenomics
    Perry, C. G.
    Maloney, K. A.
    Beitelshees, A. L.
    Jeng, L. J. B.
    Ambulos, N. P., Jr.
    Shuldiner, A. R.
    Blitzer, M. G.
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2016, 99 (06) : 582 - 584
  • [9] The 100 000 Genomes Project: bringing whole genome sequencing to the NHS
    Turnbull, Clare
    Scott, Richard H.
    Thomas, Ellen
    Jones, Louise
    Murugaesu, Nirupa
    Pretty, Freya Boardman
    Halai, Dina
    Baple, Emma
    Craig, Clare
    Hamblin, Angela
    Henderson, Shirley
    Patch, Christine
    O'Neill, Amanda
    Devereau, Andrew
    Smith, Katherine
    Martin, Antonio Rueda
    Sosinsky, Alona
    McDonagh, Ellen M.
    Sultana, Razvan
    Mueller, Michael
    Smedley, Damian
    Toms, Adam
    Dinh, Lisa
    Fowler, Tom
    Bale, Mark
    Hubbard, Tim
    Rendon, Augusto
    Hill, Sue
    Caulfield, Mark J.
    [J]. BMJ-BRITISH MEDICAL JOURNAL, 2018, 361
  • [10] Research Directions in the Clinical Implementation of Pharmacogenomics: An Overview of US Programs and Projects
    Volpi, Simona
    Bult, Carol J.
    Chisholm, Rex L.
    Deverka, Patricia A.
    Ginsburg, Geoffrey S.
    Jacob, Howard J.
    Kasapi, Melpomeni
    McLeod, Howard L.
    Roden, Dan M.
    Williams, Marc S.
    Green, Eric D.
    Rodriguez, Laura Lyman
    Aronson, Samuel
    Cavallari, Larisa H.
    Denny, Joshua C.
    Dressler, Lynn G.
    Johnson, Julie A.
    Klein, Teri E.
    Leeder, J. Steven
    Piquette-Miller, Micheline
    Perera, Minoli
    Rasmussen-Torvik, Laura J.
    Rehm, Heidi L.
    Ritchie, Marylyn D.
    Skaar, Todd C.
    Wagle, Nikhil
    Weinshilboum, Richard
    Weitzel, Kristin W.
    Wildin, Robert
    Wilson, John
    Manolio, Teri A.
    Relling, Mary V.
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2018, 103 (05) : 778 - 786
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