Targeting Eukaryotic Translation Initiation Factor 4E (eIF4E) in Cancer

被引：157

作者：

Hsieh, Andrew C. ^{[1
,2
,3
]}

Ruggero, Davide ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Sch Med, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA USA

[2] Univ Calif San Francisco, Sch Med, Dept Urol, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Div Hematol Oncol, San Francisco, CA 94143 USA

来源：

CLINICAL CANCER RESEARCH | 2010年 / 16卷 / 20期

关键词：

MESSENGER-RNA CAP; NEGATIVE BREAST-CANCER; ACUTE MYELOID-LEUKEMIA; REDUCES TUMOR-GROWTH; ANTITUMOR-ACTIVITY; BINDING-PROTEIN; GENE AMPLIFICATION; MAMMALIAN TARGET; COMPETITIVE PCR; FACTOR EIF-4E;

D O I：

10.1158/1078-0432.CCR-10-0433

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent advances in understanding the role of eukaryotic translation initiator factor 4E (eIF4E) in tumorigenesis and cancer progression have generated significant interest in therapeutic agents that indirectly or directly target aberrant activation of eIF4E in cancer. Here, we address the general function of eIF4E in translation initiation and cancer, present evidence supporting its role in cancer initiation and progression, and highlight emerging therapeutics that efficiently target hyperactivated eIF4E. In doing so, we also highlight the major differences between these therapeutics that may influence their mechanism of action. Clin Cancer Res; 16(20); 4914-20. (C) 2010 AACR.

引用

页码：4914 / 4920

页数：7

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