Abnormal Right-Hemispheric Sulcal Patterns Correlate with Executive Function in Adolescents with Tetralogy of Fallot

被引：10

作者：

Morton, Sarah U. ^{[1
,2
]}

Maleyeff, Lara ^{[3
]}

Wypij, David ^{[2
,3
,4
]}

Yun, Hyuk Jin ^{[1
,5
]}

Rollins, Caitlin K. ^{[6
,7
]}

Watson, Christopher G. ^{[6
]}

Newburger, Jane W. ^{[2
,4
]}

Bellinger, David C. ^{[6
,7
,8
,9
]}

Roberts, Amy E. ^{[2
,4
]}

Rivkin, Michael J. ^{[6
,7
,8
,10
,11
]}

Grant, P. Ellen ^{[1
,5
,9
]}

Im, Kiho ^{[1
,2
,5
]}

机构：

[1] Boston Childrens Hosp, Div Newborn Med, Boston, MA 02115 USA

[2] Harvard Med Sch, Dept Pediat, Boston, MA 02115 USA

[3] Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA

[4] Boston Childrens Hosp, Dept Cardiol, Boston, MA 02115 USA

[5] Boston Childrens Hosp, Fetal Neonatal Neuroimaging & Dev Sci Ctr, Boston, MA 02115 USA

[6] Boston Childrens Hosp, Dept Neurol, Boston, MA 02115 USA

[7] Harvard Med Sch, Dept Neurol, Boston, MA 02115 USA

[8] Boston Childrens Hosp, Dept Psychiat, Boston, MA 02115 USA

[9] Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA

[10] Boston Childrens Hosp, Div Radiol, Boston, MA 02115 USA

[11] Boston Childrens Hosp, Stroke & Cerebrovasc Ctr, Boston, MA 02115 USA

来源：

CEREBRAL CORTEX | 2021年 / 31卷 / 10期

基金：

美国国家卫生研究院;

关键词：

congenital heart disease; executive function; magnetic resonance imaging; sulcal pattern; tetralogy of Fallot; CONGENITAL HEART-DISEASE; SURFACE-BASED ANALYSIS; WHITE-MATTER MICROSTRUCTURE; ANTERIOR CINGULATE CORTEX; DE-NOVO MUTATIONS; CEREBRAL-CORTEX; NEURODEVELOPMENTAL OUTCOMES; SPATIAL-DISTRIBUTION; FOLDING PATTERNS; CHILDREN;

D O I：

10.1093/cercor/bhab114

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neurodevelopmental disabilities are the most common noncardiac conditions in patients with congenital heart disease (CHD). Executive function skills have been frequently observed to be decreased among children and adults with CHD compared with peers, but a neuroanatomical basis for the association is yet to be identified. In this study, we quantified sulcal pattern features from brain magnetic resonance imaging data obtained during adolescence among 41 participants with tetralogy of Fallot (ToF) and 49 control participants using a graph-based pattern analysis technique. Among patients with ToF, right-hemispheric sulcal pattern similarity to the control group was decreased (0.7514 vs. 0.7553, P=0.01) and positively correlated with neuropsychological testing values including executive function (r=0.48, P<0.001). Together these findings suggest that sulcal pattern analysis may be a useful marker of neurodevelopmental risk in patients with CHD. Further studies may elucidate the mechanisms leading to different alterations in sulcal patterning.

引用

页码：4670 / 4680

页数：11

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